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Thiarabine

CAT: 0013-GTR19203001-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19203001-05Size:5 mg
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Description
Thiarabine is a potent anti-tumor agent that functions by inhibiting DNA synthesis. It has demonstrated efficacy in both in vitro cell culture studies and in vivo animal models of leukemia and solid tumors, supporting its use in oncology research.
CAS Number
26599-17-7
Field of Research
Cell Biology, Molecular Biology
Smiles
Nc1ccn ([C@@H]2S[C@H] (CO) [C@@H] (O) [C@@H]2O) c (=O) n1
Molecular Formula
C9H13N3O4S
Molecular Weight
259.28
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Thiarabine

OSI-7836 is a member of the nucleoside class of cytotoxic drugs of which gemcitabine is the market leader. OSI Pharmaceuticals develops OSI-7836 as a next-generation gemcitabine. The anti-tumor activity of OSI-7836 appeares to be less schedule dependent than gemcitabine. It is also more active than ara-C (another clinically used nucleoside analog) in all nine models and more active than either paclitaxel or cisplatin in the two lung xenograft models tested. This drug shows no unexpected toxicities; those observed appeared to be similar to other nucleoside agents.

CAS Number26599-17-7
PubChem CID168566
IUPAC Name4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)thiolan-2-yl]pyrimidin-2-one
Molecular FormulaC9H13N3O4S
Molecular Weight259.28
XLogP-1.3
Topological Polar Surface Area145
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count17
Formal Charge0
Complexity386
SMILES
C1=CN(C(=O)N=C1N)[C@H]2[C@H]([C@@H]([C@H](S2)CO)O)O
InChI
InChI=1S/C9H13N3O4S/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7+,8-/m1/s1
InChIKey
GAKJJSAXUFZQTL-CCXZUQQUSA-N
Chemical Structure
2D Structure
2D structure of Thiarabine
CAS: 26599-17-7
CID: 168566
Formula: C9H13N3O4S
MW: 259.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight259.28
XLogP3-1.3
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass259.06267708
Monoisotopic Mass259.06267708
Topological Polar Surface Area145 Ų
Heavy Atom Count17
Formal Charge0
Complexity386
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A21056-100Thiarabine 100mg

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