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TUG-424

CAT: 0013-GTR19202965-02Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No
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CAT#:0013-GTR19202965-02Size:1 ml x 10 mM (in DMSO)
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TUG-424 is a potent and selective FFAR1/GPR40 agonist (EC50 = 32 nM) that markedly potentiates glucose-stimulated insulin secretion. This tool compound is valuable for investigating FFAR1's role in pancreatic beta-cell function and metabolic regulation in both in vitro and in vivo research models.
CAS Number
1082058-99-8
Product Name Alternative
FFA1/GPR40, TUG 424, TUG424, TUG-424
Field of Research
Metabolism Research, Pharmacology & Drug Discovery
Purity
98.94% (May vary between batches)
Solubility
DMSO:50 mg/mL (189.16 mM)
Smiles
Cc1ccccc1C#Cc1ccc (CCC (O) =O) cc1
Molecular Formula
C18H16O2
Molecular Weight
264.32
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Tug-424

a free fatty acid receptor 1 (FFA1) agonist

CAS Number1082058-99-8
PubChem CID25150014
IUPAC Name3-[4-[2-(2-methylphenyl)ethynyl]phenyl]propanoic acid
Molecular FormulaC18H16O2
Molecular Weight264.3
XLogP4.1
Topological Polar Surface Area37.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Heavy Atom Count20
Formal Charge0
Complexity379
SMILES
CC1=CC=CC=C1C#CC2=CC=C(C=C2)CCC(=O)O
InChI
InChI=1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20)
InChIKey
FODHWOBAQBTTFS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Tug-424
CAS: 1082058-99-8
CID: 25150014
Formula: C18H16O2
MW: 264.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight264.3
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count5
Exact Mass264.115029749
Monoisotopic Mass264.115029749
Topological Polar Surface Area37.3 Ų
Heavy Atom Count20
Formal Charge0
Complexity379
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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