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VU0483605

CAT: 0013-GTR19201639-04Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201639-04Size:10 mg
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Description
VU0483605 is a potent and selective positive allosteric modulator of the metabotropic glutamate receptor 1 (mGluR1), demonstrating EC50 values of 390 nM for human and 356 nM for rat receptors. This research compound is utilized in vitro and in vivo to investigate neurological pathways, synaptic plasticity, and conditions like pain and neurodegenerative diseases.
CAS Number
1623101-11-0
Product Name Alternative
Brain penetrant, allosteric modulator, Inhibitor, inhibit, mGluR, mGluR1, Metabotropic glutamate receptors, metabotropic glutamate, VU 0483605, VU0483605, VU-0483605
Field of Research
Neuroscience
Purity
97.03% (May vary between batches)
Solubility
DMSO:95 mg/mL (212.68 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.39 mM)
Smiles
Clc1cccc2C (=O) N (C (=O) c12) c1ccc (NC (=O) c2ncccc2Cl) cc1Cl
Molecular Formula
C20H10Cl3N3O3
Molecular Weight
446.67
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
CAS Number1623101-11-0
PubChem CID91885483
IUPAC Name3-chloro-N-[3-chloro-4-(4-chloro-1,3-dioxoisoindol-2-yl)phenyl]pyridine-2-carboxamide
Molecular FormulaC20H10Cl3N3O3
Molecular Weight446.7
XLogP4.4
Topological Polar Surface Area79.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count29
Formal Charge0
Complexity679
SMILES
C1=CC2=C(C(=C1)Cl)C(=O)N(C2=O)C3=C(C=C(C=C3)NC(=O)C4=C(C=CC=N4)Cl)Cl
InChI
InChI=1S/C20H10Cl3N3O3/c21-12-4-1-3-11-16(12)20(29)26(19(11)28)15-7-6-10(9-14(15)23)25-18(27)17-13(22)5-2-8-24-17/h1-9H,(H,25,27)
InChIKey
HJQXPBKPTGWZCF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-Chloro-N-(3-chloro-4-(4-chloro-1,3-dioxoisoindolin-2-yl)phenyl)picolinamide
CAS: 1623101-11-0
CID: 91885483
Formula: C20H10Cl3N3O3
MW: 446.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight446.7
XLogP34.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass444.978774
Monoisotopic Mass444.978774
Topological Polar Surface Area79.4 Ų
Heavy Atom Count29
Formal Charge0
Complexity679
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C5611-10VU0483605

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