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NSC33994

CAT: 0013-GTR19201048-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19201048-01Size:5 mg
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Description
NSC 33994 is a potent and selective JAK2 inhibitor with an IC50 of 60 nM, demonstrating no activity against Src or TYK2 at 25 μM. This small molecule is a valuable research tool for studying JAK-STAT signaling in hematological malignancies and inflammatory diseases in both cellular and animal models.
CAS Number
82058-16-0
Product Name Alternative
G6
Field of Research
Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Neuroscience, Signal Transduction, Stem Cell & Developmental Biology
Purity
>98%
Bioactivity
JAK2 inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 2 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming) .
Smiles
CCN (CC) Cc1cc (ccc1O) C (\CC) =C (/CC) c1ccc (O) c (CN (CC) CC) c1
Molecular Formula
C28H42N2O2
Molecular Weight
436.65
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
E-4,4’- (1,2-Diethyl-1,2-ethenediyl) bis[2-[ (diethylamino) methyl]phenol

Chemical Information

2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol
CAS Number82058-16-0
PubChem CID5473838
IUPAC Name2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol
Molecular FormulaC28H42N2O2
Molecular Weight438.6
XLogP6.7
Topological Polar Surface Area46.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Heavy Atom Count32
Formal Charge0
Complexity508
SMILES
CC/C(=C(/CC)\C1=CC(=C(C=C1)O)CN(CC)CC)/C2=CC(=C(C=C2)O)CN(CC)CC
InChI
InChI=1S/C28H42N2O2/c1-7-25(21-13-15-27(31)23(17-21)19-29(9-3)10-4)26(8-2)22-14-16-28(32)24(18-22)20-30(11-5)12-6/h13-18,31-32H,7-12,19-20H2,1-6H3/b26-25+
InChIKey
QFNJFVBKASKGEU-OCEACIFDSA-N
Chemical Structure
2D Structure
2D structure of 2-(diethylaminomethyl)-4-[(E)-4-[3-(diethylaminomethyl)-4-hydroxyphenyl]hex-3-en-3-yl]phenol
CAS: 82058-16-0
CID: 5473838
Formula: C28H42N2O2
MW: 438.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight438.6
XLogP36.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count12
Exact Mass438.324628587
Monoisotopic Mass438.324628587
Topological Polar Surface Area46.9 Ų
Heavy Atom Count32
Formal Charge0
Complexity508
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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