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MPT0B098

CAT: 0013-GTR19208267-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19208267-01Size:25 mg
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Description
MPT0B098 is a potent colchicine-site microtubule inhibitor that induces G2/M arrest and apoptosis in cancer cells, including chemoresistant lines. It uniquely destabilizes HIF-1α by inhibiting HuR-mediated mRNA export, suppressing angiogenesis in vitro and tumor growth in vivo. This compound is a valuable tool for studying microtubule biology, HIF-1α regulation, and tumor angiogenesis.
CAS Number
1254363-89-7
Smiles
S (=O) (=O) (N1C2=C (C=CC=C2CC1) C=3C=CN=CC3) C4=CC=C (OC) C=C4
Molecular Formula
C20H18N2O3S
Molecular Weight
366.43
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(4-Methoxyphenyl)sulfonyl-7-pyridin-4-yl-2,3-dihydroindole
CAS Number1254363-89-7
PubChem CID50898338
IUPAC Name1-(4-methoxyphenyl)sulfonyl-7-pyridin-4-yl-2,3-dihydroindole
Molecular FormulaC20H18N2O3S
Molecular Weight366.4
XLogP3.2
Topological Polar Surface Area67.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count26
Formal Charge0
Complexity562
SMILES
COC1=CC=C(C=C1)S(=O)(=O)N2CCC3=C2C(=CC=C3)C4=CC=NC=C4
InChI
InChI=1S/C20H18N2O3S/c1-25-17-5-7-18(8-6-17)26(23,24)22-14-11-16-3-2-4-19(20(16)22)15-9-12-21-13-10-15/h2-10,12-13H,11,14H2,1H3
InChIKey
AGYCYVPAEQVWJT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(4-Methoxyphenyl)sulfonyl-7-pyridin-4-yl-2,3-dihydroindole
CAS: 1254363-89-7
CID: 50898338
Formula: C20H18N2O3S
MW: 366.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.4
XLogP33.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass366.10381361
Monoisotopic Mass366.10381361
Topological Polar Surface Area67.9 Ų
Heavy Atom Count26
Formal Charge0
Complexity562
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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