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PD173952

CAT: 0013-GTR19199819-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19199819-02Size:5 mg
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Description
PD173952 is a small molecule inhibitor targeting Src family kinases (including Lyn), Abl, Csk, and Myt1. It induces apoptosis in Bcr-Abl-dependent hematopoietic cells and has demonstrated antitumor activity in research studies, making it a tool for investigating leukemia and related cancers in vitro.
CAS Number
305820-75-1
Product Name Alternative
Myt1, PD173952, PD-173952, PD 173952, Src
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Purity
99.50% (May vary between batches)
Solubility
DMSO:15 mg/mL (31.1 mM)
Smiles
O=C1C (=CC=2C=NC (=NC2N1C) NC3=CC=C (C=C3) N4CCOCC4) C5=C (Cl) C=CC=C5Cl
Molecular Formula
C24H21Cl2N5O2
Molecular Weight
482.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

PD-173952

PD-173952 is a potent Myt1 kinase inhibitor.

CAS Number305820-75-1
PubChem CID5328733
IUPAC Name6-(2,6-dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC24H21Cl2N5O2
Molecular Weight482.4
XLogP4.6
Topological Polar Surface Area70.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity716
SMILES
CN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=CC=C3Cl)Cl)NC4=CC=C(C=C4)N5CCOCC5
InChI
InChI=1S/C24H21Cl2N5O2/c1-30-22-15(13-18(23(30)32)21-19(25)3-2-4-20(21)26)14-27-24(29-22)28-16-5-7-17(8-6-16)31-9-11-33-12-10-31/h2-8,13-14H,9-12H2,1H3,(H,27,28,29)
InChIKey
XZEJMVDCQZRHLN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of PD-173952
CAS: 305820-75-1
CID: 5328733
Formula: C24H21Cl2N5O2
MW: 482.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight482.4
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass481.1072303
Monoisotopic Mass481.1072303
Topological Polar Surface Area70.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity716
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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