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A-65186

CAT: 0013-GTR19198369-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198369-01Size:1 mg
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Description
A-65186 is a selective CCK-A receptor antagonist used in research to investigate gastrointestinal physiology and inflammation. It is employed in both in vitro binding assays and in vivo models to study conditions like pancreatitis and gut injury.
CAS Number
119295-94-2
Product Name Alternative
CCK, A65186, A-65186, A 65186
Field of Research
Pharmacology & Drug Discovery
Purity
98.16% (May vary between batches)
Smiles
C (N[C@@H] (C (N (CCCCC) CCCCC) =O) CCC (O) =O) (=O) C1=CC2=C (N=C1) C=CC=C2
Molecular Formula
C25H35N3O4
Molecular Weight
441.56
References & Citations
Timothy O Cox et al. Intestinal interoceptive dysfunction drives age-associated cognitive decline Nature ., (2026)
Pubmed id
41813891
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

A 65186

type A CCK receptor antagonist; structure given in first source; A-70104 is the dicyclohexylammonium salt of A-65186

CAS Number119295-94-2
PubChem CID3081191
IUPAC Name(4R)-5-(dipentylamino)-5-oxo-4-(quinoline-3-carbonylamino)pentanoic acid
Molecular FormulaC25H35N3O4
Molecular Weight441.6
XLogP4.5
Topological Polar Surface Area99.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count14
Heavy Atom Count32
Formal Charge0
Complexity588
SMILES
CCCCCN(CCCCC)C(=O)[C@@H](CCC(=O)O)NC(=O)C1=CC2=CC=CC=C2N=C1
InChI
InChI=1S/C25H35N3O4/c1-3-5-9-15-28(16-10-6-4-2)25(32)22(13-14-23(29)30)27-24(31)20-17-19-11-7-8-12-21(19)26-18-20/h7-8,11-12,17-18,22H,3-6,9-10,13-16H2,1-2H3,(H,27,31)(H,29,30)/t22-/m1/s1
InChIKey
LVIZXRRZYVZZEN-JOCHJYFZSA-N
Chemical Structure
2D Structure
2D structure of A 65186
CAS: 119295-94-2
CID: 3081191
Formula: C25H35N3O4
MW: 441.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.6
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count14
Exact Mass441.26275661
Monoisotopic Mass441.26275661
Topological Polar Surface Area99.6 Ų
Heavy Atom Count32
Formal Charge0
Complexity588
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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