FR-167356

CAT: 0013-GTR19197587-07Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19197587-07Size:200 mg

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Description

FR-167356 is a potent and selective inhibitor of the a3 isoform of vacuolar H+-ATPase, demonstrating activity in osteoclast, renal, and macrophage membranes. This compound has been shown to reduce bone metastasis in B16-F10 melanoma models, making it a useful research tool for studying bone biology and cancer metastasis.

CAS Number

174185-16-1

Product Name Alternative

FR 167356, FR167356, FR-167356, Vacuolar type H+-ATPase

Field of Research

Pharmacology & Drug Discovery

Purity

98.44% (May vary between batches)

Solubility

DMSO:22.5 mg/mL (59.48 mM)

Smiles

C (C) (C) (O) C=1C=2C (=C (NC (=O) C3=C (Cl) C=CC=C3Cl) C=CC2) OC1C

Molecular Formula

C19H17Cl2NO3

Molecular Weight

378.25

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

FR167356

vacuolar ATPase inhibitor that acts particularly well on osteoclast vacuolar ATPase; structure in first source

CAS Number	174185-16-1
PubChem CID	10068207
IUPAC Name	2,6-dichloro-N-[3-(2-hydroxypropan-2-yl)-2-methyl-1-benzofuran-7-yl]benzamide
Molecular Formula	C19H17Cl2NO3
Molecular Weight	378.2
XLogP	4.5
Topological Polar Surface Area	62.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Heavy Atom Count	25
Formal Charge	0
Complexity	491

SMILES

CC1=C(C2=C(O1)C(=CC=C2)NC(=O)C3=C(C=CC=C3Cl)Cl)C(C)(C)O

InChI

InChI=1S/C19H17Cl2NO3/c1-10-16(19(2,3)24)11-6-4-9-14(17(11)25-10)22-18(23)15-12(20)7-5-8-13(15)21/h4-9,24H,1-3H3,(H,22,23)

InChIKey

GCAOVMKRBUCSET-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 174185-16-1

CID: 10068207

Formula: C19H17Cl2NO3

MW: 378.2

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	378.2
XLogP3	4.5
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	3
Exact Mass	377.0585488
Monoisotopic Mass	377.0585488
Topological Polar Surface Area	62.5 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	491
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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