Products for Research Use Only
RegisterLogin

Parsaclisib hydrochloride

CAT: 0013-GTR19196822-01Size: 25 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19196822-01Size:25 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Parsaclisib hydrochloride (INCB050465 HCl) is a potent and selective PI3Kδ inhibitor, exhibiting antitumor activity with IC50 values between 0.2 and 2 nM. It is widely used in preclinical research for studying B-cell malignancies and immune disorders, demonstrating efficacy in both in vitro cellular assays and in vivo animal models of lymphoma.
CAS Number
1995889-48-9
Field of Research
Signal Transduction
Smiles
Cl.CCOc1c (cc (Cl) c (F) c1[C@@H]1CNC (=O) C1) [C@H] (C) n1nc (C) c2c (N) ncnc12
Molecular Formula
C20H23Cl2FN6O2
Molecular Weight
469.34
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Parsaclisib Hydrochloride

Parsaclisib Hydrochloride is the hydrochloride salt form of parsaclisib, an inhibitor of the delta isoform of phosphoinositide-3 kinase (PI3K) with potential antineoplastic activity. Parsaclisib inhibits the delta isoform of PI3K and prevents the activation of the PI3K/AKT signaling pathway. This both decreases proliferation and induces cell death in PI3K-delta-overexpressing tumor cells. Unlike other isoforms of PI3K, PI3K-delta is expressed primarily in hematopoietic disease and cell lineages. The targeted inhibition of PI3K-delta is designed to preserve PI3K signaling in normal, non-neoplastic cells. PI3K, an enzyme often overexpressed in cancer cells, plays a crucial role in tumor cell regulation and survival.

CAS Number1995889-48-9
PubChem CID122507744
IUPAC Name(4R)-4-[3-[(1S)-1-(4-amino-3-methylpyrazolo[3,4-d]pyrimidin-1-yl)ethyl]-5-chloro-2-ethoxy-6-fluorophenyl]pyrrolidin-2-one;hydrochloride
Molecular FormulaC20H23Cl2FN6O2
Molecular Weight469.3
Topological Polar Surface Area108
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity632
SMILES
CCOC1=C(C(=C(C=C1[C@H](C)N2C3=NC=NC(=C3C(=N2)C)N)Cl)F)[C@H]4CC(=O)NC4.Cl
InChI
InChI=1S/C20H22ClFN6O2.ClH/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20;/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26);1H/t10-,11-;/m0./s1
InChIKey
TWHUONANZMKBKX-ACMTZBLWSA-N
Chemical Structure
2D Structure
2D structure of Parsaclisib Hydrochloride
CAS: 1995889-48-9
CID: 122507744
Formula: C20H23Cl2FN6O2
MW: 469.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight469.3
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass468.1243575
Monoisotopic Mass468.1243575
Topological Polar Surface Area108 Ų
Heavy Atom Count31
Formal Charge0
Complexity632
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19156149-01Parsaclisib
GTR19177046-01Parsaclisib
GTR19155584-01Parsaclisib HCl
GTR19224924-01NSC10010 hydrochloride
GTR19251079-01Tryptamine hydrochloride
GTR19250781Azetidine hydrochloride
GTR19157452-01Benzamil (hydrochloride)
GTR19157233-01Imeglimin hydrochloride
GTR19156886-01Propranolol hydrochloride
GTR19156853-01Dopexamine hydrochloride

Alternative Products

CatalogName
VED88948-01Parsaclisib hydrochloride
HY-109068A-01Parsaclisib (hydrochloride)
BA8737-5Parsaclisib
A13561-100Parsaclisib 100mg
A13561-50Parsaclisib 50mg
206961Parsaclisib HCl
A13561-10Parsaclisib 10mg
A13561-5Parsaclisib 5mg
A13561-1Parsaclisib 1mg
C01085-25mgParsaclisib (INCB050465)

Popular Products