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PGP-4008

CAT: 0013-GTR19196734-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19196734-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PGP-4008 is a selective and potent P-glycoprotein inhibitor. Its primary research application is in oncology, where it is used in vitro and in vivo to reverse multidrug resistance, thereby enhancing the antitumor efficacy of chemotherapeutics like Doxorubicin.
CAS Number
365565-02-2
Product Name Alternative
P-glycoprotein, Pgp, PGP4008, PGP-4008, PGP 4008
Field of Research
Metabolism Research, Neuroscience, Pharmacology & Drug Discovery
Purity
97.41% (May vary between batches)
Solubility
DMSO:50 mg/mL (127.07 mM)
Smiles
O=C (Cc1ccccc1) Nc1c2CCN (Cc3ccccc3) c2nc2ccccc12
Molecular Formula
C26H23N3O
Molecular Weight
393.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pgp-4008
CAS Number365565-02-2
PubChem CID9821937
IUPAC NameN-(1-benzyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-yl)-2-phenylacetamide
Molecular FormulaC26H23N3O
Molecular Weight393.5
XLogP4.9
Topological Polar Surface Area45.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count30
Formal Charge0
Complexity569
SMILES
C1CN(C2=NC3=CC=CC=C3C(=C21)NC(=O)CC4=CC=CC=C4)CC5=CC=CC=C5
InChI
InChI=1S/C26H23N3O/c30-24(17-19-9-3-1-4-10-19)28-25-21-13-7-8-14-23(21)27-26-22(25)15-16-29(26)18-20-11-5-2-6-12-20/h1-14H,15-18H2,(H,27,28,30)
InChIKey
HVIAKQBMYMKWII-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pgp-4008
CAS: 365565-02-2
CID: 9821937
Formula: C26H23N3O
MW: 393.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight393.5
XLogP34.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass393.184112366
Monoisotopic Mass393.184112366
Topological Polar Surface Area45.2 Ų
Heavy Atom Count30
Formal Charge0
Complexity569
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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