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RN9893

CAT: 0013-GTR19196610-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19196610-01Size:2 mg
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Description
RN9893 is a potent and selective TRPV4 channel antagonist, exhibiting IC50 values of 320 nM (mouse), 420 nM (human), and 660 nM (rat) . It is a valuable research tool for investigating TRPV4's role in pain, pulmonary edema, and skeletal dysplasia in both cellular and animal models.
CAS Number
1803003-68-0
Product Name Alternative
RN9893, RN-9893, RN 9893, RN 9893 Hydrochloride, TRPV4, TRPVChannel, TRPV Channel, TRPChannel, TRP Channel
Field of Research
Pharmacology & Drug Discovery
Purity
99.89% (May vary between batches)
Solubility
DMSO:200 mg/mL (399.61 mM)
Smiles
C (NC1=CC=C (S (=O) (=O) N2CCN (C (C) C) CC2) C=C1) (=O) C3=C (N (=O) =O) C=C (C (F) (F) F) C=C3
Molecular Formula
C21H23F3N4O5S
Molecular Weight
500.49
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

RN-9893

structure in first source

CAS Number1803003-68-0
PubChem CID121513880
IUPAC Name2-nitro-N-[4-(4-propan-2-ylpiperazin-1-yl)sulfonylphenyl]-4-(trifluoromethyl)benzamide
Molecular FormulaC21H23F3N4O5S
Molecular Weight500.5
XLogP3.2
Topological Polar Surface Area124
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Heavy Atom Count34
Formal Charge0
Complexity827
SMILES
CC(C)N1CCN(CC1)S(=O)(=O)C2=CC=C(C=C2)NC(=O)C3=C(C=C(C=C3)C(F)(F)F)[N+](=O)[O-]
InChI
InChI=1S/C21H23F3N4O5S/c1-14(2)26-9-11-27(12-10-26)34(32,33)17-6-4-16(5-7-17)25-20(29)18-8-3-15(21(22,23)24)13-19(18)28(30)31/h3-8,13-14H,9-12H2,1-2H3,(H,25,29)
InChIKey
KORKKQLDGMHNKO-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of RN-9893
CAS: 1803003-68-0
CID: 121513880
Formula: C21H23F3N4O5S
MW: 500.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight500.5
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count10
Rotatable Bond Count5
Exact Mass500.13412551
Monoisotopic Mass500.13412551
Topological Polar Surface Area124 Ų
Heavy Atom Count34
Formal Charge0
Complexity827
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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