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Isosteviol

CAT: 0804-HY-N0872-01Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-N0872-01Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Isosteviol ((-) -Isosteviol) is a derivative of Stevioside through acid catalyzed hydrolysis of Stevioside. Isosteviol inhibits DNA polymerase and DNA topoisomerase and has antibacterial, anticancer and anti-tuberculosis effects[1][2][3][4].
CAS Number
27975-19-5
Product Name Alternative
(-) -Isosteviol; iso-Steviol
UNSPSC
12352211
Hazard Statement
H302-H315-H319-H335
Target
Interleukin Related; Reactive Oxygen Species (ROS) ; Topoisomerase
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Isosteviol.html
Purity
98.0
Solubility
DMSO : ≥ 100 mg/mL
Smiles
C[C@]([C@]1([H])CC2)(CCC[C@@]1(C)C(O)=O)[C@@]3([H])[C@@]2(CC4=O)C[C@]4(C)CC3
Molecular Formula
C20H30O3
Molecular Weight
318.45
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Wong KL, et al. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci. 2004 Mar 26;74 (19) :2379-87.|[2]Wong KL, et al. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med. 2004 Feb;70 (2) :108-12.|[3]Wong KL, et al. Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. Pharmacology. 2006;76 (4) :163-9.|[4]Asad Ullah, et al. Bioactivity Profile of the Diterpene Isosteviol and its Derivatives. Molecules. 2019 Feb 14;24 (4) :678.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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