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Oxamflatin

CAT: 0804-HY-102033-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-102033-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Oxamflatin (Metacept-3) is a potent HDAC inhibitor with an IC50 of 15.7 nM. Oxamflatin is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
151720-43-3
Product Name Alternative
Metacept-3
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Oxamflatin.html
Concentration
10mM
Purity
98.13
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NO)/C=C/C#CC1=CC=CC(NS(=O)(C2=CC=CC=C2)=O)=C1
Molecular Formula
C17H14N2O4S
Molecular Weight
342.37
References & Citations
[1]Kim YB, et al. Oxamflatin is a novel antitumor compound that inhibits mammalian histone deacetylase. Oncogene. 1999 Apr 15;18 (15) :2461-70.|[2]Wang YL, et al. HDAC Inhibitor Oxamflatin Induces Morphological Changes and has Strong Cytostatic Effects in Ovarian Cancer Cell Lines. Curr Mol Med. 2016;16 (3) :232-42.|[3]Faghihloo E, et al. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016 Nov;23 (11) :396-399.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC

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