Cortodoxone

CAT: 0804-HY-77839-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0804-HY-77839-01Size:25 mg
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Description
Cortodoxone (11-Deoxycortisol; cortexolone) is a glucocorticoid steroid hormone and also is a glucocorticoid antagonist. Cortodoxone increases tryptophan oxygenase (TO) activity and induces the secretion of corticosterone. Cortodoxone regulates T cell proliferation and activation[1][2].
CAS Number
[152-58-9]
Product Name Alternative
11-Deoxycortisol; cortexolone; Reichstein's substance S
UNSPSC
12352211
Hazard Statement
H410
Target
Endogenous Metabolite; Glucocorticoid Receptor
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Endocrinology
Assay Protocol
https://www.medchemexpress.com/Cortodoxone.html
Purity
98.74
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
Molecular Formula
C21H30O4
Molecular Weight
346.47
Precautions
H410
References & Citations
[1]Gjerde H, et al. 11-Deoxycortisol induces hepatic tryptophan oxygenase in rats. Acta Pharmacol Toxicol (Copenh) . 1985 Jul;57 (1) :36-9. |[2]Peng C, et al. 11-deoxycortisol positively correlates with T cell immune traits in physiological conditions. EBioMedicine. 2024 Jan;99:104935.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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