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2'-O,4'-C-Methyleneuridine

CAT: 0013-GTR19191967-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191967-01Size:1 mg
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Description
2'-O,4'-C-Methyleneuridine is a bicyclic nucleoside analog featuring a locked C3'-endo sugar conformation. This structure enhances RNA affinity and nuclease resistance, making it valuable for oligonucleotide therapeutic research, including antisense and siRNA applications in vitro and in vivo.
CAS Number
200435-92-3
Product Name Alternative
2' O,4' C Methyleneuridine, 2'-O,4'-C-Methyleneuridine, 2'O,4'CMethyleneuridine
Field of Research
Cell Biology, Molecular Biology
Purity
97.42% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (15.61 mM) ; DMSO:100 mg/mL (390.3 mM)
Smiles
C (O) [C@@]12O[C@H] ([C@@] ([C@@H]1O) (OC2) [H]) N3C (=O) NC (=O) C=C3
Molecular Formula
C10H12N2O6
Molecular Weight
256.21
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-((1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione
CAS Number200435-92-3
PubChem CID15546052
IUPAC Name1-[(1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl]pyrimidine-2,4-dione
Molecular FormulaC10H12N2O6
Molecular Weight256.21
XLogP-2.2
Topological Polar Surface Area108
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity438
SMILES
C1[C@]2([C@H]([C@@H](O1)[C@@H](O2)N3C=CC(=O)NC3=O)O)CO
InChI
InChI=1S/C10H12N2O6/c13-3-10-4-17-6(7(10)15)8(18-10)12-2-1-5(14)11-9(12)16/h1-2,6-8,13,15H,3-4H2,(H,11,14,16)/t6-,7+,8-,10+/m1/s1
InChIKey
KNLNWXXWKDEEFW-JIOCBJNQSA-N
Chemical Structure
2D Structure
2D structure of 1-((1S,3R,4R,7S)-7-hydroxy-1-(hydroxymethyl)-2,5-dioxabicyclo[2.2.1]heptan-3-yl)pyrimidine-2,4(1H,3H)-dione
CAS: 200435-92-3
CID: 15546052
Formula: C10H12N2O6
MW: 256.21
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight256.21
XLogP3-2.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count2
Exact Mass256.06953611
Monoisotopic Mass256.06953611
Topological Polar Surface Area108 Ų
Heavy Atom Count18
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA4300-1002’-O,4’-C-Methyleneuridine
T35653-012'-O,4'-C-Methyleneuridine
HY-1543715’-O-Benzoyl-2’-O,4’-C-methyleneuridine
TNU1577-015'-O-Benzoyl-2'-O,4'-C-methyleneuridine
T75186-015'-O-Benzoyl-3'-O- (4-methoxybenzyl) -2'-O,4'-C-methyleneuridine
MBS58171115'-O-Benzoyl-3'-O-(4-methoxybenzyl)-2'-O,4'-C-methyleneuridine
HY-1540405’-O-Benzoyl-3’-O- (4-methoxybenzyl) -2’-O,4’-C-methyleneuridine
TNU1249-015'-O-Benzoyl-3'-O- (4-methoxybenzoyl) -2'-O,4'-C-methyleneuridine
MBS58268435'-O-Benzoyl-3'-O-(4-methoxybenzoyl)-2'-O,4'-C-methyleneuridine
HY-1540425’-Azido-5’-deoxy-2’-O,4’-C-methyleneuridine

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