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ALK4290

CAT: 0013-GTR19191273-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191273-02Size:50 mg
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Description
ALK4290 is a potent, orally active small molecule CCR3 antagonist with a Ki of 3.2 nM for human CCR3. It is a research tool for investigating diseases like neovascular age-related macular degeneration and Parkinsonism, with applications in both in vitro and in vivo experimental models.
CAS Number
1251528-23-0
Field of Research
Immunology & Inflammation, Infectious Disease & Virology, Pharmacology & Drug Discovery
Smiles
CN (C) C (=O) c1cc (C) nc (NC (=O) [C@H]2CCC (=O) N2C2CCN (Cc3ccc (Cl) c (C) c3) CC2) c1
Molecular Formula
C27H34ClN5O3
Molecular Weight
512.04
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Lazucirnon

ALK-4290 is under investigation in clinical trial NCT03558061 (Evaluate the Effects and Safety of ALK4290 in Patients With Newly Diagnosed Wet Age-Related Macular Degeneration).

CAS Number1251528-23-0
PubChem CID59534386
IUPAC Name2-[[(2R)-1-[1-[(4-chloro-3-methylphenyl)methyl]piperidin-4-yl]-5-oxopyrrolidine-2-carbonyl]amino]-N,N,6-trimethylpyridine-4-carboxamide
Molecular FormulaC27H34ClN5O3
Molecular Weight512.0
XLogP2.9
Topological Polar Surface Area85.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count36
Formal Charge0
Complexity802
SMILES
CC1=CC(=CC(=N1)NC(=O)[C@H]2CCC(=O)N2C3CCN(CC3)CC4=CC(=C(C=C4)Cl)C)C(=O)N(C)C
InChI
InChI=1S/C27H34ClN5O3/c1-17-13-19(5-6-22(17)28)16-32-11-9-21(10-12-32)33-23(7-8-25(33)34)26(35)30-24-15-20(14-18(2)29-24)27(36)31(3)4/h5-6,13-15,21,23H,7-12,16H2,1-4H3,(H,29,30,35)/t23-/m1/s1
InChIKey
DWKNOLCXIFYNFV-HSZRJFAPSA-N
Chemical Structure
2D Structure
2D structure of Lazucirnon
CAS: 1251528-23-0
CID: 59534386
Formula: C27H34ClN5O3
MW: 512.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight512.0
XLogP32.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass511.2350177
Monoisotopic Mass511.2350177
Topological Polar Surface Area85.9 Ų
Heavy Atom Count36
Formal Charge0
Complexity802
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
HY-136788-01ALK4290
T85626-01ALK4290 dihydrochloride
HY-136788AALK4290 (dihydrochloride)

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