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BPIQ-II (hydrochloride)

CAT: 0013-GTR19191142-01Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191142-01Size:500 µg
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Description
BPIQ-II is a potent and highly selective linear imidazoloquinazoline inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 8 pM) . It acts as a competitive ATP-site binder, effectively blocking EGF-stimulated signaling in cellular assays, making it a valuable tool for cancer research and studying EGFR-driven pathways in vitro.
CAS Number
171179-37-6
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
Cl.BrC1=CC=CC (=C1) NC2=NC=NC3=CC=4N=CNC4C=C32
Molecular Formula
C15H11BrClN5
Molecular Weight
376.64
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

BPIQ-II (hydrochloride)
CAS Number171179-37-6
PubChem CID132988087
IUPAC NameN-(3-bromophenyl)-1H-imidazo[4,5-g]quinazolin-8-amine;hydrochloride
Molecular FormulaC15H11BrClN5
Molecular Weight376.64
Topological Polar Surface Area66.5
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity368
SMILES
C1=CC(=CC(=C1)Br)NC2=NC=NC3=CC4=C(C=C32)NC=N4.Cl
InChI
InChI=1S/C15H10BrN5.ClH/c16-9-2-1-3-10(4-9)21-15-11-5-13-14(19-7-18-13)6-12(11)17-8-20-15;/h1-8H,(H,18,19)(H,17,20,21);1H
InChIKey
FENLVGDZGJBHPT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of BPIQ-II (hydrochloride)
CAS: 171179-37-6
CID: 132988087
Formula: C15H11BrClN5
MW: 376.64
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight376.64
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass374.98864
Monoisotopic Mass374.98864
Topological Polar Surface Area66.5 Ų
Heavy Atom Count22
Formal Charge0
Complexity368
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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