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PKUMDL-LC-101-D04

CAT: 0013-GTR19191014-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19191014-01Size:1 mg
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Description
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a key regulator of ferroptosis. It elevates GPX4 activity in cell-free and cellular assays, as demonstrated in wild-type MEFs, and protects cells from cholesterol peroxide-induced ferroptotic death. This compound is a valuable research tool for investigating ferroptosis in both in vitro and in vivo models.
CAS Number
2143896-83-5
Product Name Alternative
PKUMDL-LC-101-D04, Gpx4, GPX4-Activator-1d4
Field of Research
Metabolism Research
Purity
98.71% (May vary between batches)
Solubility
DMSO:225 mg/mL (593.76 mM)
Smiles
Cl.NCCNS (=O) (=O) c1ccc (NC (=S) NC2CCCC2) cc1
Molecular Formula
C14H23ClN4O2S2
Molecular Weight
378.94
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Pkumdl-LC-101-D04
CAS Number2143896-83-5
PubChem CID155543553
IUPAC Name1-[4-(2-aminoethylsulfamoyl)phenyl]-3-cyclopentylthiourea;hydrochloride
Molecular FormulaC14H23ClN4O2S2
Molecular Weight378.9
Topological Polar Surface Area137
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count23
Formal Charge0
Complexity450
SMILES
C1CCC(C1)NC(=S)NC2=CC=C(C=C2)S(=O)(=O)NCCN.Cl
InChI
InChI=1S/C14H22N4O2S2.ClH/c15-9-10-16-22(19,20)13-7-5-12(6-8-13)18-14(21)17-11-3-1-2-4-11;/h5-8,11,16H,1-4,9-10,15H2,(H2,17,18,21);1H
InChIKey
FELDRJSFLBINQS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pkumdl-LC-101-D04
CAS: 2143896-83-5
CID: 155543553
Formula: C14H23ClN4O2S2
MW: 378.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight378.9
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass378.0950960
Monoisotopic Mass378.0950960
Topological Polar Surface Area137 Ų
Heavy Atom Count23
Formal Charge0
Complexity450
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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