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DDRI-18

CAT: 0013-GTR19200378-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19200378-04Size:25 mg
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Description
DDRI-18 is a novel small molecule that disrupts the DNA damage response by inhibiting non-homologous end joining (NHEJ) . It acts as a chemosensitizer, enhancing the cytotoxicity of DNA-damaging agents in cancer research, with demonstrated efficacy in both in vitro and in vivo experimental models.
CAS Number
4402-18-0
Product Name Alternative
DDRI18, DDRI-18, DDRI 18, DNA/RNA Synthesis, DNA Synthesis, DNASynthesis, RNASynthesis, RNA Synthesis
Field of Research
Cell Biology, Molecular Biology
Solubility
DMSO:20 mg/mL (48.02 mM)
Smiles
NC=1C=C (C=2NC=3C (N2) =CC=C (C3) C=4C=C5C (=CC4) N=C (N5) C6=CC (N) =CC=C6) C=CC1
Molecular Formula
C26H20N6
Molecular Weight
416.48
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

3-[6-[2-(3-aminophenyl)-3H-benzimidazol-5-yl]-1H-benzimidazol-2-yl]aniline
CAS Number4402-18-0
PubChem CID4644404
IUPAC Name3-[6-[2-(3-aminophenyl)-3H-benzimidazol-5-yl]-1H-benzimidazol-2-yl]aniline
Molecular FormulaC26H20N6
Molecular Weight416.5
XLogP4.6
Topological Polar Surface Area109
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count32
Formal Charge0
Complexity590
SMILES
C1=CC(=CC(=C1)N)C2=NC3=C(N2)C=C(C=C3)C4=CC5=C(C=C4)N=C(N5)C6=CC(=CC=C6)N
InChI
InChI=1S/C26H20N6/c27-19-5-1-3-17(11-19)25-29-21-9-7-15(13-23(21)31-25)16-8-10-22-24(14-16)32-26(30-22)18-4-2-6-20(28)12-18/h1-14H,27-28H2,(H,29,31)(H,30,32)
InChIKey
QROWVLFOWUYBIG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[6-[2-(3-aminophenyl)-3H-benzimidazol-5-yl]-1H-benzimidazol-2-yl]aniline
CAS: 4402-18-0
CID: 4644404
Formula: C26H20N6
MW: 416.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight416.5
XLogP34.6
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass416.17494466
Monoisotopic Mass416.17494466
Topological Polar Surface Area109 Ų
Heavy Atom Count32
Formal Charge0
Complexity590
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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