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K-8012

CAT: 0013-GTR19200158-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19200158-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
K-8012 is a selective modulator of the N-terminally truncated isoform of RXRα (tRXRα) . Its RXRα-dependent mechanism enhances antitumor effects, making it a valuable research tool for studying retinoid X receptor signaling in cancer biology, both in vitro and in vivo.
CAS Number
1346513-17-4
Product Name Alternative
K8012, K-8012, K 8012, RAR, RetinoidReceptor, retinoid X receptor α, Retinoid Receptor, RXR
Field of Research
Cell Biology, Metabolism Research, Signal Transduction
Purity
98.24% (May vary between batches)
Solubility
DMSO:60 mg/mL (160.24 mM)
Smiles
C (=C/1\C=2C (C (CCC=3NN=NN3) =C1C) =CC (F) =CC2) \C4=CC=C (C (C) C) C=C4
Molecular Formula
C23H23FN4
Molecular Weight
374.45
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5-(2-{(1z)-5-Fluoro-2-Methyl-1-[4-(Propan-2-Yl)benzylidene]-1h-Inden-3-Yl}ethyl)-1h-Tetrazole
CAS Number1346513-17-4
PubChem CID54589362
IUPAC Name5-[2-[(3Z)-6-fluoro-2-methyl-3-[(4-propan-2-ylphenyl)methylidene]inden-1-yl]ethyl]-2H-tetrazole
Molecular FormulaC23H23FN4
Molecular Weight374.5
XLogP4.8
Topological Polar Surface Area54.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Heavy Atom Count28
Formal Charge0
Complexity606
SMILES
CC\1=C(C2=C(/C1=C\C3=CC=C(C=C3)C(C)C)C=CC(=C2)F)CCC4=NNN=N4
InChI
InChI=1S/C23H23FN4/c1-14(2)17-6-4-16(5-7-17)12-21-15(3)19(10-11-23-25-27-28-26-23)22-13-18(24)8-9-20(21)22/h4-9,12-14H,10-11H2,1-3H3,(H,25,26,27,28)/b21-12-
InChIKey
XBRDZHUUARVXDN-MTJSOVHGSA-N
Chemical Structure
2D Structure
2D structure of 5-(2-{(1z)-5-Fluoro-2-Methyl-1-[4-(Propan-2-Yl)benzylidene]-1h-Inden-3-Yl}ethyl)-1h-Tetrazole
CAS: 1346513-17-4
CID: 54589362
Formula: C23H23FN4
MW: 374.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight374.5
XLogP34.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count5
Exact Mass374.19067491
Monoisotopic Mass374.19067491
Topological Polar Surface Area54.5 Ų
Heavy Atom Count28
Formal Charge0
Complexity606
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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