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Phox-I1

CAT: 0013-GTR19198750-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19198750-01Size:25 mg
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Description
Phox-I1 is a selective small molecule inhibitor of the NADPH oxidase 2 (NOX2) complex. It functions by disrupting the critical protein-protein interaction between the p67phox subunit and Rac GTPase, thereby blocking superoxide production. This inhibitor is a valuable research tool for studying NOX2's role in oxidative stress, inflammation, and related pathologies in both cellular and animal models.
CAS Number
1388151-90-3
Field of Research
Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
COc1ccc2OC (N3N=C (CC3c2c1) c1ccccc1) c1cccc (c1) [N+] ([O-]) =O
Molecular Formula
C23H19N3O4
Molecular Weight
401.41
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Phox-I1
CAS Number1388151-90-3
PubChem CID3721292
IUPAC Name9-methoxy-5-(3-nitrophenyl)-2-phenyl-5,10b-dihydro-1H-pyrazolo[1,5-c][1,3]benzoxazine
Molecular FormulaC23H19N3O4
Molecular Weight401.4
XLogP4.6
Topological Polar Surface Area79.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count30
Formal Charge0
Complexity659
SMILES
COC1=CC2=C(C=C1)OC(N3C2CC(=N3)C4=CC=CC=C4)C5=CC(=CC=C5)[N+](=O)[O-]
InChI
InChI=1S/C23H19N3O4/c1-29-18-10-11-22-19(13-18)21-14-20(15-6-3-2-4-7-15)24-25(21)23(30-22)16-8-5-9-17(12-16)26(27)28/h2-13,21,23H,14H2,1H3
InChIKey
VTKZDTUTWZFSRQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Phox-I1
CAS: 1388151-90-3
CID: 3721292
Formula: C23H19N3O4
MW: 401.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.4
XLogP34.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass401.13755610
Monoisotopic Mass401.13755610
Topological Polar Surface Area79.9 Ų
Heavy Atom Count30
Formal Charge0
Complexity659
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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