SKI2852

CAT: 0013-GTR19196478-03Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19196478-03Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

SKI2852 is a potent, selective, and orally bioavailable inhibitor of 11β-HSD1. It has demonstrated efficacy in ameliorating metabolic syndrome parameters in diabetic rodent models, supporting its use in research on type 2 diabetes, obesity, and glucocorticoid metabolism.

CAS Number

1346554-47-9

Product Name Alternative

SKI 2852, SKI2852, SKI-2852, SK I 2852, SK I2852, SK I-2852

Field of Research

Metabolism Research

Purity

99.89% (May vary between batches)

Smiles

N (C (=O) C1=NC (=NC=C1) N2[C@H] (C) CN (CC2) C3=C (F) C=C (S (C) (=O) =O) C=C3) [C@@H]4[C@]5 (CC6 (O) C[C@@]4 (CC (C5) C6) [H]) [H]

Molecular Formula

C27H34FN5O4S

Molecular Weight

543.65

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

2-((R)-4-(2-Fluoro-4-(methylsulfonyl)phenyl)-2-methylpiperazin-1-yl)-N-((1R,2s,3S,5S,7S)-5-hydroxyadamantan-2-yl)pyrimidine-4-carboxamide

CAS Number	1346554-47-9
PubChem CID	135905445
IUPAC Name	2-[(2R)-4-(2-fluoro-4-methylsulfonylphenyl)-2-methylpiperazin-1-yl]-N-[(1S,3R)-5-hydroxy-2-adamantyl]pyrimidine-4-carboxamide
Molecular Formula	C27H34FN5O4S
Molecular Weight	543.7
XLogP	2.8
Topological Polar Surface Area	124
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Heavy Atom Count	38
Formal Charge	0
Complexity	994

SMILES

C[C@@H]1CN(CCN1C2=NC=CC(=N2)C(=O)NC3[C@@H]4CC5C[C@H]3CC(C4)(C5)O)C6=C(C=C(C=C6)S(=O)(=O)C)F

InChI

InChI=1S/C27H34FN5O4S/c1-16-15-32(23-4-3-20(11-21(23)28)38(2,36)37)7-8-33(16)26-29-6-5-22(30-26)25(34)31-24-18-9-17-10-19(24)14-27(35,12-17)13-18/h3-6,11,16-19,24,35H,7-10,12-15H2,1-2H3,(H,31,34)/t16-,17?,18-,19+,24?,27?/m1/s1

InChIKey

SSKKTEYBWOVEET-GMILZOMTSA-N

Chemical Structure

2D Structure

CAS: 1346554-47-9

CID: 135905445

Formula: C27H34FN5O4S

MW: 543.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	543.7
XLogP3	2.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	5
Exact Mass	543.23155392
Monoisotopic Mass	543.23155392
Topological Polar Surface Area	124 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	994
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
HY-19325-01	SKI2852

SKI2852

Chemical Information

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