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Velutin

CAT: 0013-GTR19190150-02Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19190150-02Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Velutin is a potent flavone with significant anti-inflammatory properties, effectively inhibiting NF-κB activation, stabilizing IκBα, and suppressing p38/JNK phosphorylation. This activity translates to robust reductions in pro-inflammatory cytokines like TNF-α and IL-6, making it a valuable research tool for studying inflammation pathways in cellular models.
CAS Number
25739-41-7
Product Name Alternative
HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF, HIF/HIFProlylHydroxylase, HIF/HIF ProlylHydroxylase, Inhibitor, HIF-1α, HIFProlylHydroxylase, Melanin, inhibit, NF-κB, NFκB, NF-kB, NFkB, osteoclast, biosynthesis, differentiation, Velutin
Field of Research
Epigenetics & Chromatin, Metabolism Research, Signal Transduction
Purity
99.69% (May vary between batches)
Solubility
DMSO:10 mM
Smiles
COc1cc (O) c2c (c1) oc (cc2=O) -c1ccc (O) c (OC) c1
Molecular Formula
C17H14O6
Molecular Weight
314.29
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

5,4'-Dihydroxy-7,3'-dimethoxyflavone

Velutin is a dimethoxyflavone that is luteolin in which the hydroxy groups at positions 7 and 3' are replaced by methoxy groups. It has a role as an antioxidant, an antibacterial agent, an anti-allergic agent, a melanin synthesis inhibitor, an anti-inflammatory agent and a plant metabolite. It is a dimethoxyflavone and a dihydroxyflavone. It is functionally related to a 4',5,7-trihydroxy-3'-methoxyflavone.

CAS Number25739-41-7
PubChem CID5464381
IUPAC Name5-hydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxychromen-4-one
Molecular FormulaC17H14O6
Molecular Weight314.29
XLogP2
Topological Polar Surface Area85.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count23
Formal Charge0
Complexity476
SMILES
COC1=CC(=C2C(=C1)OC(=CC2=O)C3=CC(=C(C=C3)O)OC)O
InChI
InChI=1S/C17H14O6/c1-21-10-6-12(19)17-13(20)8-14(23-16(17)7-10)9-3-4-11(18)15(5-9)22-2/h3-8,18-19H,1-2H3
InChIKey
ROCUOVBWAWAQFD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5,4'-Dihydroxy-7,3'-dimethoxyflavone
CAS: 25739-41-7
CID: 5464381
Formula: C17H14O6
MW: 314.29
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight314.29
XLogP32
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass314.07903816
Monoisotopic Mass314.07903816
Topological Polar Surface Area85.2 Ų
Heavy Atom Count23
Formal Charge0
Complexity476
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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