TLR1 rabbit pAb

TLR1 rabbit pAb

• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. [provided by RefSeq, Jul 2008],
• Synonyms: TLR1; KIAA0012; Toll-like receptor 1; Toll/interleukin-1 receptor-like protein; TIL; CD281
• Gene ID: 7096
• UniProt: Q15399
• Cellular Locus: Cell membrane ; Single-pass type I membrane protein. Cytoplasmic vesicle, phagosome membrane ; Single-pass type I membrane protein. Membrane raft. Golgi apparatus. Does not reside in lipid rafts before stimulation but accumulates increasingly in the raft upon the presence of the microbial ligand. In response to triacylated lipoproteins, TLR2:TLR1 heterodimers are recruited in lipid rafts, this recruitment determine the intracellular targeting to the Golgi apparatus..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: Recombinant Protein of TLR1
• Clonality: Polyclonal
• Validated Applications: IHC, IF
• Stability: 1 year
• Dilution: IHC: 1:200-500
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.