YS-49

Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Dry Ice Shipment: No

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MBS3845629-02	YS-49
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BA5100-50	YS-49
MBS5754144-04	YS-49
T13376-50mg	YS-49
T13376-10mg	YS-49
MBS3845629-04	YS-49

YS-49

CAT:

804-HY-15477-03

Size:

5 mg

Price:

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For price, please contact [email protected].

CAS Number: 132836-42-1
UNSPSC Description: YS-49 is a PI3K/Akt (a downstream target of RhoA) activator, to reduce RhoA/PTEN activation in the 3-methylcholanthrene-treated cells. YS-49 inhibits angiotensin II (Ang II)-stimulated proliferation of VSMCs via induction of heme oxygenase (HO)-1. YS-49 is also an isoquinoline compound alkaloid, has a strong positive inotropic action through activation of cardiac β-adrenoceptors[1][2][3].
Target Antigen: Adrenergic Receptor; Akt; Angiotensin Receptor; PI3K
Type: Reference compound
Related Pathways: GPCR/G Protein;Neuronal Signaling;PI3K/Akt/mTOR
Applications: COVID-19-immunoregulation
Field of Research: Cardiovascular Disease; Endocrinology
Assay Protocol: https://www.medchemexpress.com/ys-49.html
Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : 10 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles: OC1=CC2=C(C(CC3=C4C=CC=CC4=CC=C3)NCC2)C=C1O.[H]Br
Molecular Weight: 386.28
References & Citations: [1]Sun JJ, Kim HJ, Seo HG, et al. YS49,1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1. Life Sci. 2008;82(11-12):600-7.|[2]Kang YJ, et al. Prevention of the expression of inducible nitric oxide synthase by a novel positive inotropic agent, YS 49, in rat vascular smooth muscle and RAW 264.7 macrophages. Br J Pharmacol. 1999 Sep;128(2):357-64.|[3]Hsu YH, et al. RhoA-mediated inhibition of vascular endothelial cell mobility: positive feedback through reduced cytosolic p21 and p27. J Cell Physiol. 2014 Oct;229(10):1455-65.
Shipping Conditions: Room Temperature
Clinical Information: No Development Reported

Complementary Product Range

Our range of products, including YS-49, falls within the same field of application and can be used across various research projects. These products are carefully selected for their high performance and reliability, supporting the diverse needs of modern laboratories. Whether for ongoing studies or future experiments, they are designed to help researchers achieve their scientific goals. Here are some related products that may be of interest for similar or future applications:

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Cat	Name
HY-15477-03	YS-49
HY-15477-01	YS-49
HY-15477-04	YS-49
HY-15477-02	YS-49
HY-15477A-02	YS-49 (monohydrate)
HY-15477A-01	YS-49 (monohydrate)
HY-15477A-04	YS-49 (monohydrate)
HY-15477A-03	YS-49 (monohydrate)
HY-U00137-05	YS-201
HY-157413-05	YS-67