Products for Research Use Only
RegisterLogin

NCB-0846

CAT: 0013-GTR19189067-04Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19189067-04Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
NCB-0846 is a potent, cell-permeable small molecule inhibitor targeting TNIK with an IC50 of 21 nM. It is utilized in biochemical and cellular research to investigate Wnt signaling pathways and has shown efficacy in reducing tumor growth in preclinical colorectal cancer models.
CAS Number
1792999-26-8
Product Name Alternative
Betacatenin, beta-catenin, bcatenin, inhibit, Inhibitor, NCB 0846, NCB0846, NCB-0846, MAPK Kinase Kinase Kinase, MAP4K, TNIK, Wnt/b-catenin, Wnt, Wnt/betacatenin, Wnt/β-catenin, βcatenin
Field of Research
Signal Transduction, Stem Cell & Developmental Biology
Purity
97.04% (May vary between batches)
Solubility
DMSO:50 mg/mL (133.18 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.33 mM)
Smiles
O[C@H]1CC[C@H] (CC1) Oc1cccc2cnc (Nc3ccc4nc[nH]c4c3) nc12
Molecular Formula
C21H21N5O2
Molecular Weight
375.42
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cis-4-{[2-(1h-Benzimidazol-5-Ylamino)quinazolin-8-Yl]oxy}cyclohexanol
CAS Number1792999-26-8
PubChem CID91801204
IUPAC Name4-[2-(3H-benzimidazol-5-ylamino)quinazolin-8-yl]oxycyclohexan-1-ol
Molecular FormulaC21H21N5O2
Molecular Weight375.4
XLogP3.6
Topological Polar Surface Area96
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity515
SMILES
C1CC(CCC1O)OC2=CC=CC3=CN=C(N=C32)NC4=CC5=C(C=C4)N=CN5
InChI
InChI=1S/C21H21N5O2/c27-15-5-7-16(8-6-15)28-19-3-1-2-13-11-22-21(26-20(13)19)25-14-4-9-17-18(10-14)24-12-23-17/h1-4,9-12,15-16,27H,5-8H2,(H,23,24)(H,22,25,26)
InChIKey
FYWRWBSYRGSWIQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cis-4-{[2-(1h-Benzimidazol-5-Ylamino)quinazolin-8-Yl]oxy}cyclohexanol
CAS: 1792999-26-8
CID: 91801204
Formula: C21H21N5O2
MW: 375.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.4
XLogP33.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count6
Rotatable Bond Count4
Exact Mass375.16952493
Monoisotopic Mass375.16952493
Topological Polar Surface Area96 Ų
Heavy Atom Count28
Formal Charge0
Complexity515
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19208889-01N 0840
GTR18011204NCB2 Antibody
GTR17954574NCBP Antibody
GTR18144698Cytomegalovirus Antibody [0841]
GTR18018145Ncb2 Antibody
GTR18003846NCBP Antibody
GTR19106449-01Recombinant Invertebrate iridescent virus 6 Uncharacterized protein 084L (IIV6-084L)
GTR19171348-01PRE-084 hydrochloride
GTR19156828-01PRE-084 hydrochloride
GTR17964549Ncbp-1 Antibody

Alternative Products

CatalogName
BA6478-100NCB-0846

Popular Products