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OTS514

CAT: 0013-GTR19188481-08Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188481-08Size:200 mg
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Description
OTS514 hydrochloride is a potent and selective TOPK inhibitor with nanomolar IC50 values against small cell lung cancer (SCLC) cell lines. It suppresses tumor growth by inhibiting FOXM1 activity and demonstrates enhanced cytotoxicity against CD90-positive and sphere-derived cancer stem-like cells in vitro.
CAS Number
1338540-63-8
Product Name Alternative
TOPK, positive, Inhibitor, HMCL, OTS 514, OTS 514 Hydrochloride, OTS514 Hydrochloride, OTS-514 Hydrochloride, OTS514, OTS-514, OTS514 HCl, myeloma, multiple, inhibit, cell, cycle, Apoptosis, arrest, cancer
Field of Research
Cell Biology, Signal Transduction
Purity
99.62% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.05 mM) ; DMSO:90 mg/mL (246.94 mM)
Smiles
C[C@@H] (CN) c1ccc (cc1) -c1c (O) cc (C) c2[nH]c (=O) c3sccc3c12
Molecular Formula
C21H20N2O2S
Molecular Weight
364.46
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

(R)-9-(4-(1-aminopropan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one
CAS Number1338540-63-8
PubChem CID67448836
IUPAC Name9-[4-[(2R)-1-aminopropan-2-yl]phenyl]-8-hydroxy-6-methyl-5H-thieno[2,3-c]quinolin-4-one
Molecular FormulaC21H20N2O2S
Molecular Weight364.5
XLogP3.8
Topological Polar Surface Area104
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity522
SMILES
CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)[C@@H](C)CN)O
InChI
InChI=1S/C21H20N2O2S/c1-11-9-16(24)17(14-5-3-13(4-6-14)12(2)10-22)18-15-7-8-26-20(15)21(25)23-19(11)18/h3-9,12,24H,10,22H2,1-2H3,(H,23,25)/t12-/m0/s1
InChIKey
OETLNMOJNONWOY-LBPRGKRZSA-N
Chemical Structure
2D Structure
2D structure of (R)-9-(4-(1-aminopropan-2-yl)phenyl)-8-hydroxy-6-methylthieno[2,3-c]quinolin-4(5H)-one
CAS: 1338540-63-8
CID: 67448836
Formula: C21H20N2O2S
MW: 364.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight364.5
XLogP33.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass364.12454906
Monoisotopic Mass364.12454906
Topological Polar Surface Area104 Ų
Heavy Atom Count26
Formal Charge0
Complexity522
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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