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Cridanimod sodium

CAT: 0013-GTR19188369-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19188369-02Size:5 mg
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Description
Cridanimod sodium
CAS Number
58880-43-6
Field of Research
Immunology & Inflammation, Pharmacology & Drug Discovery
Smiles
[Na+].[O-]C (=O) CN1C2=C (C=CC=C2) C (=O) C2=C1C=CC=C2
Molecular Formula
C15H11NNaO3
Molecular Weight
276.24
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Cridanimod Sodium

Cridanimod Sodium is the sodium salt form of cridanimod, a small molecule that can increase progesterone receptor (PR) expression, with potential antineoplastic adjuvant activity. Upon intramuscular administration, cridanimod is able to induce the expression of PR in endometrial cancer. This could increase the sensitivity of endometrial cancer cells to progestin monotherapy. In combination with a progestin, cancer cells could be eradicated through increased PR-mediated signaling, leading to an inhibition of luteinizing hormone (LH) release from the pituitary gland, via a negative feedback mechanism, and, eventually, an inhibition of estrogen release from the ovaries. This leads to an inhibition of cellular growth in estrogen-dependent tumor cells. In addition, this agent is able to increase the production and release of interferon (IFN) alpha and beta. PR is often downregulated in endometrial cancer and makes it resistant to progestin-mediated hormone therapy.

CAS Number58880-43-6
PubChem CID23684339
IUPAC Namesodium 2-(9-oxoacridin-10-yl)acetate
Molecular FormulaC15H10NNaO3
Molecular Weight275.23
Topological Polar Surface Area60.4
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count20
Formal Charge0
Complexity361
SMILES
C1=CC=C2C(=C1)C(=O)C3=CC=CC=C3N2CC(=O)[O-].[Na+]
InChI
InChI=1S/C15H11NO3.Na/c17-14(18)9-16-12-7-3-1-5-10(12)15(19)11-6-2-4-8-13(11)16;/h1-8H,9H2,(H,17,18);/q;+1/p-1
InChIKey
FQMLTEAEJZVTAJ-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Cridanimod Sodium
CAS: 58880-43-6
CID: 23684339
Formula: C15H10NNaO3
MW: 275.23
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight275.23
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass275.05583746
Monoisotopic Mass275.05583746
Topological Polar Surface Area60.4 Ų
Heavy Atom Count20
Formal Charge0
Complexity361
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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