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DIF-3

CAT: 0013-GTR19187988-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19187988-05Size:25 mg
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Description
DIF-3 is a research compound that activates GSK-3β, leading to the degradation of cyclin D1 and c-Myc and inhibition of Wnt/β-catenin signaling. It demonstrates antiproliferative effects in vitro, such as in HeLa and DLD-1 cancer cell lines, making it a tool for studying oncogenic pathways.
CAS Number
113411-17-9
Product Name Alternative
GSK-3β, GSK3, betacatenin, beta-catenin, Cyclin D1, bcatenin, βcatenin, Wnt/β-catenin, Wnt, Wnt/betacatenin, Wnt/b-catenin
Field of Research
Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Purity
98.00% (May vary between batches)
Solubility
10% DMSO+90% Corn Oil:3.3 mg/mL (12.1 mM) ; DMSO:90 mg/mL (330.01 mM)
Smiles
CCCCCC (=O) c1c (O) cc (OC) c (Cl) c1O
Molecular Formula
C13H17ClO4
Molecular Weight
272.72
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone

structure given in first source; endogenous differentiation-inducing factor; induces stalk-cell differentiation in the cellular slime mold Dictyostelium discoideum

CAS Number113411-17-9
PubChem CID3081033
IUPAC Name1-(3-chloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one
Molecular FormulaC13H17ClO4
Molecular Weight272.72
XLogP4
Topological Polar Surface Area66.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count18
Formal Charge0
Complexity272
SMILES
CCCCCC(=O)C1=C(C(=C(C=C1O)OC)Cl)O
InChI
InChI=1S/C13H17ClO4/c1-3-4-5-6-8(15)11-9(16)7-10(18-2)12(14)13(11)17/h7,16-17H,3-6H2,1-2H3
InChIKey
JWBMZIJMSBFBIY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-(3-Chloro-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone
CAS: 113411-17-9
CID: 3081033
Formula: C13H17ClO4
MW: 272.72
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight272.72
XLogP34
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass272.0815367
Monoisotopic Mass272.0815367
Topological Polar Surface Area66.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity272
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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