Prekallikrein Heavy Chain (Kininogenin, Fletcher factor, KLKB1, KLK3)

• NCBI Gene ID:

  3818

• Reactivity:

  Human

• Storage Conditions:

  Ships on ice packs. Upon receipt, aliquot and store at -20°C. Avoid multiple freeze/thaw cycles. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

• Specificity:

  Recognizes two variants (88 kDa and 85 kDa) of prekallikrein and its activation products kallikrein (88 kDa and 85 kDa), the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and Antithrombin III, and 45 kDa prekallikrein/kallikrein fragment(s). Recognizes prekallikrein and its activation products in human, chimpanzee, rhesus, and baboon plasmas. The epitope for this antibody, located on the prekallikrein/kallikrein heavy chain, is involved in the interaction between prekallikrein and factor XIIa. This antibody inhibits prekallikrein activation in human and rhesus plasmas by approximately 60-80% and 55%, respectively. This antibody does not cross-react with tissue kallikrein.

• Other Gene Names:

  [KLKB1; KLKB1; PPK; KLK3; KLK3]

• Short Name:

  [Prekallikrein Heavy Chain]

• Other Product Names:

  [Plasma kallikrein; Plasma kallikrein; plasma kallikrein; kininogenin; Fletcher factor; plasma prekallikrein; plasma kallikrein heavy chain; plasma kallikrein light chain; kallikrein B, plasma (Fletcher factor) 1; Fletcher factor; Kininogenin; Plasma prekallikrein]

• NCBI GI Number:

  125184

• NCBI Accession Number:

  P03952.1

• Uniprot Accession Number:

  P03952