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DNA Methyltransferase 3A (Dnmt 3A)

CAT: 0544-MBS601364-01Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0544-MBS601364-01Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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NCBI Gene ID
444984
Reactivity
Human, Mouse
Storage Conditions
May be stored at 4 °C for short-term only. For long-term storage, store at -20 °C. Aliquots are stable for at least 12 months at -20 °C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Specificity
Methylation of DNA at cytosine residues plays an important role in regulation of gene expression, genomic imprinting and is essential for mammalian development. Hypermethylation of CpG islands in tumor suppressor genes or hypomethylation of bulk genomic DNA may be linked with development of cancer. To date, 3 families of mammalian DNA methyltransferase genes have been identified which include Dnmt1, Dnmt2 and Dnmt3. Dnmt1 is constitutively expressed in proliferating cells and inactivation of this gene causes global demethylation of genomic DNA and embryonic lethality. Dnmt2 is expressed at low levels in adult tissues and its inactivation does not affect DNA methylation or maintenance of methylation. The Dnmt3 family members, Dnmt3a and Dnmt3b, are strongly expressed in ES cells but their expression is down regulated in differentiating ES cells and is low in adult somatic tissue. Recently, it has been shown that naturally occurring mutations of Dnmt3b gene occurs in patients with a rare autosomal recessive disorder, termed ICF (immunodeficiency, centromeric instability, and facial anomalies) syndrome.
Other Gene Names
[Dnmt3a; Dnmt3a; MGC109195]
Short Name
[DNA Methyltransferase 3A]
Other Product Names
[DNA (cytosine-5)-methyltransferase 3A isoform 2; DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5)-methyltransferase 3A; DNA (cytosine-5)-methyltransferase 3A; DNA methyltransferase 3A; DNA (cytosine-5-)-methyltransferase 3 alpha]
NCBI GI Number
51556265
NCBI Accession Number
NP_001003957.1
NCBI GB Accession Number
NM_001003957.1
Uniprot Accession Number
Q1LZ53

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