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NFATc1-IN-1

CAT: 0013-GTR19187010-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19187010-01Size:5 mg
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Description
NFATc1-IN-1 (compound A04) is a potent inhibitor of RANKL-induced osteoclastogenesis (IC50 = 1.57 μM) that acts by blocking NFATc1 nuclear translocation. This mechanism supports its utility in foundational research on bone resorption disorders, including in vitro studies of osteoporosis and rheumatoid arthritis pathways.
CAS Number
1912422-56-0
Product Name Alternative
RANK, RANKL
Field of Research
Signal Transduction
Purity
99.64% (May vary between batches)
Solubility
DMSO:112.5 mg/mL (299.91 mM)
Smiles
C (NC1=C (F) C=C (I) C=C1) (=O) C2=C (O) C=CC (F) =C2
Molecular Formula
C13H8F2INO2
Molecular Weight
375.11
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

NFATc1-IN-1
CAS Number1912422-56-0
PubChem CID127043724
IUPAC Name5-fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxybenzamide
Molecular FormulaC13H8F2INO2
Molecular Weight375.11
XLogP3.8
Topological Polar Surface Area49.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count19
Formal Charge0
Complexity332
SMILES
C1=CC(=C(C=C1F)C(=O)NC2=C(C=C(C=C2)I)F)O
InChI
InChI=1S/C13H8F2INO2/c14-7-1-4-12(18)9(5-7)13(19)17-11-3-2-8(16)6-10(11)15/h1-6,18H,(H,17,19)
InChIKey
IGRCFOGPIJEESA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of NFATc1-IN-1
CAS: 1912422-56-0
CID: 127043724
Formula: C13H8F2INO2
MW: 375.11
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight375.11
XLogP33.8
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass374.95678
Monoisotopic Mass374.95678
Topological Polar Surface Area49.3 Ų
Heavy Atom Count19
Formal Charge0
Complexity332
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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