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FLT3-IN-12

CAT: 0013-GTR19186192-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186192-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FLT3-IN-12 is a potent and orally bioavailable FLT3 inhibitor with high selectivity over c-KIT, demonstrating low nanomolar activity against FLT3-WT and FLT3-D835Y mutants. It exhibits strong anti-proliferative effects in FLT3-ITD-positive MV4-11 AML cells and has shown efficacy in preclinical in vivo models of acute myeloid leukemia.
CAS Number
2499966-67-3
Field of Research
Cardiovascular Research, Cell Biology, Signal Transduction
Smiles
O=C1C=2C (=CC (NC=3N=C (N[C@@H]4CC[C@H] (N) CC4) C (C (F) (F) F) =CN3) =CC2) C=CN1C
Molecular Formula
C21H23F3N6O
Molecular Weight
432.44
Storage Conditions
-20°C
Notes
For research use only.

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