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MAX-40279

CAT: 0013-GTR19186088-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186088-02Size:50 mg
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Description
MAX-40279 is a potent dual inhibitor targeting both FLT3 and FGFR kinases. It is a candidate for acute myeloid leukemia (AML) research, showing potential in preclinical studies for investigating oncogenic signaling pathways in both cellular and animal models.
CAS Number
2070931-57-4
Field of Research
Cardiovascular Research, Signal Transduction
Smiles
COc1cc (F) ccc1-c1c (C) sc2cnc (Nc3cnn (c3) C3CCNCC3) nc12
Molecular Formula
C22H23FN6OS
Molecular Weight
438.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

7-(4-Fluoro-2-methoxyphenyl)-6-methyl-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl) thieno (3,2-d)pyrimidin-2-amine

MAX-40279 is under investigation in clinical trial NCT03412292 (MAX-40279 in Subjects With Acute Myelogenous Leukemia (AML)).

CAS Number2070931-57-4
PubChem CID126495573
IUPAC Name7-(4-fluoro-2-methoxyphenyl)-6-methyl-N-(1-piperidin-4-ylpyrazol-4-yl)thieno[3,2-d]pyrimidin-2-amine
Molecular FormulaC22H23FN6OS
Molecular Weight438.5
XLogP3.6
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count31
Formal Charge0
Complexity598
SMILES
CC1=C(C2=NC(=NC=C2S1)NC3=CN(N=C3)C4CCNCC4)C5=C(C=C(C=C5)F)OC
InChI
InChI=1S/C22H23FN6OS/c1-13-20(17-4-3-14(23)9-18(17)30-2)21-19(31-13)11-25-22(28-21)27-15-10-26-29(12-15)16-5-7-24-8-6-16/h3-4,9-12,16,24H,5-8H2,1-2H3,(H,25,27,28)
InChIKey
AVIOBQFPAGEICQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-(4-Fluoro-2-methoxyphenyl)-6-methyl-N-(1-(piperidin-4-yl)-1H-pyrazol-4-yl) thieno (3,2-d)pyrimidin-2-amine
CAS: 2070931-57-4
CID: 126495573
Formula: C22H23FN6OS
MW: 438.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight438.5
XLogP33.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass438.16380871
Monoisotopic Mass438.16380871
Topological Polar Surface Area105 Ų
Heavy Atom Count31
Formal Charge0
Complexity598
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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