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QW24

CAT: 0013-GTR19185976-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19185976-01Size:50 mg
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Description
QW24 is a small molecule inhibitor that downregulates the BMI-1 oncoprotein, demonstrating potent antitumor activity. It has shown efficacy in both in vitro and in vivo models of colorectal cancer, supporting its investigation as a potential therapeutic agent in oncology research.
CAS Number
2416312-06-4
Field of Research
Cell Biology, Molecular Biology
Smiles
C[C@@]12C=3C (=CC (C (NC4=CC=C (OC) C=C4) =O) =C (OC) C3) CCC1 (C (C) (C) C (=O) C (C#N) =C2) [H]
Molecular Formula
C27H28N2O4
Molecular Weight
444.52
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

CID 162641639
CAS Number2416312-06-4
PubChem CID162641639
IUPAC Name(4bS)-6-cyano-3-methoxy-N-(4-methoxyphenyl)-4b,8,8-trimethyl-7-oxo-9,10-dihydro-8aH-phenanthrene-2-carboxamide
Molecular FormulaC27H28N2O4
Molecular Weight444.5
XLogP5
Topological Polar Surface Area88.4
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count33
Formal Charge0
Complexity863
SMILES
C[C@]12C=C(C(=O)C(C1CCC3=CC(=C(C=C23)OC)C(=O)NC4=CC=C(C=C4)OC)(C)C)C#N
InChI
InChI=1S/C27H28N2O4/c1-26(2)23-11-6-16-12-20(25(31)29-18-7-9-19(32-4)10-8-18)22(33-5)13-21(16)27(23,3)14-17(15-28)24(26)30/h7-10,12-14,23H,6,11H2,1-5H3,(H,29,31)/t23?,27-/m1/s1
InChIKey
LXIJEBDQJLDKLX-IQHZPMLTSA-N
Chemical Structure
2D Structure
2D structure of CID 162641639
CAS: 2416312-06-4
CID: 162641639
Formula: C27H28N2O4
MW: 444.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight444.5
XLogP35
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass444.20490738
Monoisotopic Mass444.20490738
Topological Polar Surface Area88.4 Ų
Heavy Atom Count33
Formal Charge0
Complexity863
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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