Artemisitene

• Description:

  Artemisitene, a natural derivative of Artemisinin, is a Nrf2 activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability[1][2].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Keap1-Nrf2; Topoisomerase

• Type:

  Natural Products

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage; NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/artemisitene.html

• Purity:

  99.93

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  C=C1[C@@](CC[C@H]2C)([H])[C@@]([C@@]2([H])CC3)(OO4)[C@@](OC1=O)([H])O[C@@]34C

• Molecular Formula:

  C15H20O5

• Molecular Weight:

  280.32

• References & Citations:

  [1]Weimin Chen, et al. Artemisitene activates the Nrf2-dependent antioxidant response and protects against bleomycin-induced lung injury. FASEB J. 2016 Jul;30 (7) :2500-10.|[2]Jian Chen, et al. Artemisitene suppresses tumorigenesis by inducing DNA damage through deregulating c-Myc-topoisomerase pathway. Oncogene. 2018 Sep;37 (37) :5079-5087.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• CAS Number:

  [101020-89-7]