Exarafenib

CAT: 0013-GTR19184992-07Size: 1 ml x 10 mM (in DMSO)Dry Ice: NoHazardous: No

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CAT#:0013-GTR19184992-07Size:1 ml x 10 mM (in DMSO)

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Description

Exarafenib (RAF/KIN_2787) is an orally bioavailable, pan-RAF inhibitor that suppresses the MAPK signaling pathway, demonstrating antitumor efficacy. It is utilized in cancer research for investigating RAF-driven malignancies in both cellular and animal models.

CAS Number

2639957-39-2

Product Name Alternative

Exarafenib, p38MAPK, p38 MAPK, RAF/KIN_2787

Field of Research

Signal Transduction

Purity

98.36% (May vary between batches)

Solubility

DMSO:50 mg/mL (95.86 mM) ;10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.83 mM)

Smiles

C[C@H] (CO) Nc1cc (cc (n1) N1CCOCC1) -c1cc (NC (=O) N2CC[C@@H] (CC (F) (F) F) C2) ccc1C

Molecular Formula

C26H34F3N5O3

Molecular Weight

521.58

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Exarafenib

Exarafenib is an orally available inhibitor of class I, II, and III B-Raf (BRAF) protein kinases, with potential antineoplastic activity. Upon administration, exarafenib binds to and inhibits Class I, Class II, or Class III B-Raf mutations. This prevents B-Raf-mediated signal transduction pathways, which may lead to an inhibition of tumor growth in B-Raf mutant cells. B-Raf protein kinases play a key role in the RAF/MEK/ERK signaling pathway, which is often deregulated and mutated in human cancers, and plays a key role in tumor cell proliferation and survival.

CAS Number	2639957-39-2
PubChem CID	156297592
IUPAC Name	(3S)-N-[3-[2-[[(2R)-1-hydroxypropan-2-yl]amino]-6-morpholin-4-yl-4-pyridinyl]-4-methylphenyl]-3-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide
Molecular Formula	C26H34F3N5O3
Molecular Weight	521.6
XLogP	4
Topological Polar Surface Area	90
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Heavy Atom Count	37
Formal Charge	0
Complexity	739

SMILES

CC1=C(C=C(C=C1)NC(=O)N2CC[C@H](C2)CC(F)(F)F)C3=CC(=NC(=C3)N4CCOCC4)N[C@H](C)CO

InChI

InChI=1S/C26H34F3N5O3/c1-17-3-4-21(31-25(36)34-6-5-19(15-34)14-26(27,28)29)13-22(17)20-11-23(30-18(2)16-35)32-24(12-20)33-7-9-37-10-8-33/h3-4,11-13,18-19,35H,5-10,14-16H2,1-2H3,(H,30,32)(H,31,36)/t18-,19+/m1/s1

InChIKey

GZMYLSJUNSCMTD-MOPGFXCFSA-N

Chemical Structure

2D Structure

CAS: 2639957-39-2

CID: 156297592

Formula: C26H34F3N5O3

MW: 521.6

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	521.6
XLogP3	4
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	9
Rotatable Bond Count	7
Exact Mass	521.26137445
Monoisotopic Mass	521.26137445
Topological Polar Surface Area	90 Å²
Heavy Atom Count	37
Formal Charge	0
Complexity	739
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
BA6513-50	Exarafenib

Exarafenib

Chemical Information

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