Nitazoxanide

• Description :

  Nitazoxanide (NTZ), an anthelmintic agent, exhibits a broad spectrum of activities against a wide variety of helminths, protozoa, and enteric bacteria infecting animals and humans. Nitazoxanide inhibits Giardia lamblia trophozoite proliferation in axenic culture with an IC50 of 2.4 μM[1]. Nitazoxanide can be used for the research of parasitic gastroenteritis. Nitazoxanide shows anti-Japanese encephalitis virus (JEV) activity in a mouse model[2].

• Product Name Alternative :

  NTZ; NSC 697855

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Autophagy; Influenza Virus; Parasite

• Type :

  Reference compound

• Related Pathways :

  Anti-infection; Autophagy

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Cancer; Infection

• Assay Protocol :

  https://www.medchemexpress.com/nitazoxanide.html

• Concentration :

  10mM

• Purity :

  99.95

• Solubility :

  DMSO : ≥ 100 mg/mL

• Smiles :

  O=C(NC1=NC=C([N+]([O-])=O)S1)C2=CC=CC=C2OC(C)=O

• Molecular Formula :

  C12H9N3O5S

• Molecular Weight :

  307.28

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Rossignol JF, et al. Thiazolides, a new class of anti-influenza molecules targeting viral hemagglutinin at the post-translational level. J Biol Chem. 2009 Oct 23;284 (43) :29798-808.|[2]Zixue Shi, et al. Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model. Virol J. 2014 Jan 23;11:10.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• CAS Number :

  [55981-09-4]