Linvencorvir

CAT: 0013-GTR19184483-02Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19184483-02Size:5 mg

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Description

Linvencorvir is a small molecule therapeutic candidate that modifies the hepatitis B virus core protein. It is used in research to investigate novel mechanisms for suppressing HBV replication in both cellular and animal models of chronic infection.

CAS Number

1808248-05-6

Product Name Alternative

Linvencorvir, HBV, Antibiotic, RG 7907, RG7907, RG-7907

Field of Research

Cell Biology, Infectious Disease & Virology

Purity

99.78% (May vary between batches)

Solubility

DMSO:128.8 mg/mL (215.14 mM)

Smiles

C (OCC) (=O) C=1[C@@H] (NC (=NC1CN2C[C@@]3 (N (CC2) C (=O) N (CC (C (O) =O) (C) C) C3) [H]) C4=NC=CS4) C5=C (C) C (F) =CC=C5

Molecular Formula

C29H35FN6O5S

Molecular Weight

598.69

Storage Conditions

-20°C

Notes

For research use only.

Chemical Information

Linvencorvir

Linvencorvir is a small molecule drug. The usage of the INN stem '-corvir' in the name indicates that Linvencorvir is a core protein (Cp) inhibitor. Linvencorvir is under investigation in clinical trial NCT04225715 (A Trial To Evaluate The Efficacy And Safety Of Multiple Combination Therapies In Participants With Chronic Hepatitis B). Linvencorvir has a monoisotopic molecular weight of 598.24 Da.

CAS Number	1808248-05-6
PubChem CID	118354396
IUPAC Name	3-[(8aS)-7-[[(4S)-5-ethoxycarbonyl-4-(3-fluoro-2-methylphenyl)-2-(1,3-thiazol-2-yl)-1,4-dihydropyrimidin-6-yl]methyl]-3-oxo-5,6,8,8a-tetrahydro-1H-imidazo[1,5-a]pyrazin-2-yl]-2,2-dimethylpropanoic acid
Molecular Formula	C29H35FN6O5S
Molecular Weight	598.7
XLogP	-0.1
Topological Polar Surface Area	156
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Heavy Atom Count	42
Formal Charge	0
Complexity	1130

SMILES

CCOC(=O)C1=C(NC(=N[C@H]1C2=C(C(=CC=C2)F)C)C3=NC=CS3)CN4CCN5[C@@H](C4)CN(C5=O)CC(C)(C)C(=O)O

InChI

InChI=1S/C29H35FN6O5S/c1-5-41-26(37)22-21(15-34-10-11-36-18(13-34)14-35(28(36)40)16-29(3,4)27(38)39)32-24(25-31-9-12-42-25)33-23(22)19-7-6-8-20(30)17(19)2/h6-9,12,18,23H,5,10-11,13-16H2,1-4H3,(H,32,33)(H,38,39)/t18-,23-/m0/s1

InChIKey

YLJBFYZGSKMBEZ-MBSDFSHPSA-N

Chemical Structure

2D Structure

CAS: 1808248-05-6

CID: 118354396

Formula: C29H35FN6O5S

MW: 598.7

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	598.7
XLogP3	-0.1
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	598.23736757
Monoisotopic Mass	598.23736757
Topological Polar Surface Area	156 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	1130
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
M35768-01	Linvencorvir
HY-145579R	Linvencorvir (Standard)

Linvencorvir

Chemical Information

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