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NSC781406

CAT: 0804-HY-100470-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100470-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.
CAS Number
1676893-24-5
UNSPSC
12352005
Target
MTOR; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NSC781406.html
Purity
99.97
Solubility
DMSO : 150 mg/mL (ultrasonic)
Smiles
FC1=CC(F)=CC=C1S(=O)(NC2=CC(C3=CC=C(N=CC=C4C#CCN5CCN(S(C)(=O)=O)CC5)C4=C3)=CN=C2OC)=O
Molecular Formula
C29H27F2N5O5S2
Molecular Weight
627.68
References & Citations
[1]Chen Y, et al. Discovery of benzenesulfonamide derivatives as potent PI3K/mTOR dual inhibitors with in vivo efficacies against hepatocellular carcinoma. Bioorg Med Chem. 2016 Mar 1;24 (5) :957-66.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MTOR; PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

Alternative Products

CatalogName
BA8709-50NSC781406
A20402-200NSC781406 200mg
A20402-25NSC781406 25mg
A20402-10NSC781406 10mg
A20402-5NSC781406 5mg
A20402-2NSC781406 2mg
A20402-1NSC781406 1mg
A20402-100NSC781406 100mg
A20402-50NSC781406 50mg
A20402-10mM-DNSC781406 10mM * 1mL in DMSO

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