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DCeMM1

CAT: 0013-GTR19184252-06Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184252-06Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCeMM1 is a molecular glue degrader that induces the CRL4DCAF15 E3 ligase to target and degrade the RNA-binding protein RBM39, as demonstrated by reduced RBM39 levels in WT KBM7 cells. This tool compound is used in vitro to study targeted protein degradation, splicing regulation, and cancer biology.
CAS Number
118719-16-7
Product Name Alternative
Molecular Glues, MolecularGlues, dCeMM1
Field of Research
Pharmacology & Drug Discovery
Purity
99.29% (May vary between batches)
Solubility
DMSO:1.8 mg/mL (4.88 mM)
Smiles
Cc1ccc (cc1) S (=O) (=O) NN=Cc1cc (Br) ccc1O
Molecular Formula
C14H13BrN2O3S
Molecular Weight
369.23
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

N'-(5-Bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide

DCeMM1 is a RBM39 glue degrader. dCeMM1 shows functions by re-directing the activity of the CRL4DCAF15 ligase. dCeMM1 decreases the expression of RBM39 levels in WT KBM7 cells.

CAS Number118719-16-7
PubChem CID135541690
IUPAC NameN-[(E)-(5-bromo-2-hydroxyphenyl)methylideneamino]-4-methylbenzenesulfonamide
Molecular FormulaC14H13BrN2O3S
Molecular Weight369.24
XLogP3.2
Topological Polar Surface Area87.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count21
Formal Charge0
Complexity455
SMILES
CC1=CC=C(C=C1)S(=O)(=O)N/N=C/C2=C(C=CC(=C2)Br)O
InChI
InChI=1S/C14H13BrN2O3S/c1-10-2-5-13(6-3-10)21(19,20)17-16-9-11-8-12(15)4-7-14(11)18/h2-9,17-18H,1H3/b16-9+
InChIKey
PBEIAQYKTXKQGF-CXUHLZMHSA-N
Chemical Structure
2D Structure
2D structure of N'-(5-Bromo-2-hydroxybenzylidene)-4-methylbenzenesulfonohydrazide
CAS: 118719-16-7
CID: 135541690
Formula: C14H13BrN2O3S
MW: 369.24
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight369.24
XLogP33.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass367.98303
Monoisotopic Mass367.98303
Topological Polar Surface Area87.1 Ų
Heavy Atom Count21
Formal Charge0
Complexity455
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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