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AG-10

CAT: 0013-GTR19183589-05Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19183589-05Size:25 mg
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Description
AG-10 (Acoramidis) is a selective, orally bioavailable kinetic stabilizer of transthyretin (TTR), effective against both wild-type and V122I mutant forms. It is a research tool for studying TTR amyloidosis, with applications in preclinical in vitro binding assays and in vivo models of amyloid deposition.
CAS Number
1446711-81-4
Product Name Alternative
AG 10, AG10, AG-10, Acoramidis, Transthyretin
Purity
99.74% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (3.42 mM) ; DMSO:4.8 mg/mL (16.42 mM)
Smiles
O (CCCC=1C (C) =NNC1C) C2=CC (C (O) =O) =CC=C2F
Molecular Formula
C15H17FN2O3
Molecular Weight
292.31
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

Acoramidis

Acoramidis is a small molecule stabilizer of transthyretin (TTR) for use in patients with TTR amyloidosis. Similar to the previously developed [tafamidis], acoramidis is used to stabilize TTR in its tetrameric form, preventing the formation of amyloidogenic monomers and the progression of amyloidosis. Although they share a mechanism of action, acoramidis is more selective for TTR and is a more potent stabilizer when compared to tafamidis. Acoramidis has been in development since at least 2013. It was brought to market by BridgeBio Pharma and approved by the FDA in November 2024 to reduce negative cardiovascular outcomes in patients with cardiomyopathy caused by TTR amyloidosis.

CAS Number1446711-81-4
PubChem CID71464713
IUPAC Name3-[3-(3,5-dimethyl-1H-pyrazol-4-yl)propoxy]-4-fluorobenzoic acid
Molecular FormulaC15H17FN2O3
Molecular Weight292.30
XLogP2.9
Topological Polar Surface Area75.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count21
Formal Charge0
Complexity356
SMILES
CC1=C(C(=NN1)C)CCCOC2=C(C=CC(=C2)C(=O)O)F
InChI
InChI=1S/C15H17FN2O3/c1-9-12(10(2)18-17-9)4-3-7-21-14-8-11(15(19)20)5-6-13(14)16/h5-6,8H,3-4,7H2,1-2H3,(H,17,18)(H,19,20)
InChIKey
WBFUHHBPNXWNCC-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Acoramidis
CAS: 1446711-81-4
CID: 71464713
Formula: C15H17FN2O3
MW: 292.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight292.30
XLogP32.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass292.12232057
Monoisotopic Mass292.12232057
Topological Polar Surface Area75.2 Ų
Heavy Atom Count21
Formal Charge0
Complexity356
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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