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Tarenflurbil

CAT: 0804-HY-10291-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-10291-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tarenflurbil ((R) -Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R) -Flurbiprofen) inhibits the binding of [3H]9-cis-RA to RXRα LBD with IC50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research.
CAS Number
51543-40-9
Product Name Alternative
(R) -Flurbiprofen; MPC7869
UNSPSC
12352005
Hazard Statement
H301+H311, H317, H361
Target
Autophagy; RAR/RXR
Type
Reference compound
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/_R_-Flurbiprofen.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(O)[C@H](C)C1=CC=C(C2=CC=CC=C2)C(F)=C1
Molecular Formula
C15H13FO2
Molecular Weight
244.26
Precautions
H301+H311, H317, H361
References & Citations
[1]You X, et al. Retinoid X receptor-alpha mediates (R) -flurbiprofen's effect on the levels of Alzheimer's beta-amyloid. J Neurochem. 2009 Oct;111 (1) :142-9.|[2]Wanngren J, et al. Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem. 2012 Sep 21;287 (39) :32640-50.|[3]Schmitz K, et al. R-flurbiprofen attenuates experimental autoimmune encephalomyelitis in mice. EMBO Mol Med. 2014 Sep 30;6 (11) :1398-422.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3

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