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Selnoflast

CAT: 0013-GTR19186738-02Size: 250 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19186738-02Size:250 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Selnoflast is a selective small molecule inhibitor targeting the NLRP3 inflammasome. It is a valuable research tool for investigating NLRP3-driven pathologies in both cellular and animal models of inflammatory and autoimmune diseases.
CAS Number
2260969-36-4
Product Name Alternative
NLRP3, RO-7486967, RG 6418
Field of Research
Immunology & Inflammation, Signal Transduction
Purity
>99.99% (May vary between batches)
Solubility
NaOH:2 mg/mL (5.11 mM) ; DMSO:2 mg/mL (5.11 mM)
Smiles
CCN1CCC (CC1) S (=O) (=O) NC (=O) Nc1c2CCCc2cc2CCCc12
Molecular Formula
C20H29N3O3S
Molecular Weight
391.53
Storage Conditions
Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Notes
For research use only.

Chemical Information

Selnoflast

Selnoflast is a small molecule drug. The usage of the INN stem '-noflast' in the name indicates that Selnoflast is a inflammasome protein NLRP3 inhibitor. Selnoflast is under investigation in clinical trial NCT05924243 (A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease.). Selnoflast has a monoisotopic molecular weight of 391.19 Da.

CAS Number2260969-36-4
PubChem CID137402358
IUPAC Name1-(1-ethylpiperidin-4-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea
Molecular FormulaC20H29N3O3S
Molecular Weight391.5
XLogP3.7
Topological Polar Surface Area86.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity619
SMILES
CCN1CCC(CC1)S(=O)(=O)NC(=O)NC2=C3CCCC3=CC4=C2CCC4
InChI
InChI=1S/C20H29N3O3S/c1-2-23-11-9-16(10-12-23)27(25,26)22-20(24)21-19-17-7-3-5-14(17)13-15-6-4-8-18(15)19/h13,16H,2-12H2,1H3,(H2,21,22,24)
InChIKey
OHIFQOUPTWBQLE-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Selnoflast
CAS: 2260969-36-4
CID: 137402358
Formula: C20H29N3O3S
MW: 391.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight391.5
XLogP33.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass391.19296297
Monoisotopic Mass391.19296297
Topological Polar Surface Area86.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity619
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C01919-01Selnoflast
T78614-01Selnoflast potassium
MBS5820276Selnoflast calcium
HY-132831ASelnoflast (calcium)
HY-132831BSelnoflast (potassium)
HY-132831CSelnoflast (monopotassium)

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