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OTS447

CAT: 0013-GTR19185590-04Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19185590-04Size:25 mg
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Description
OTS447 is a potent and selective FLT3 tyrosine kinase inhibitor with an IC50 of 21 nM. It is a valuable research tool for investigating acute myeloid leukemia (AML), demonstrating activity in both cellular assays and in vivo xenograft models.
CAS Number
1356943-67-3
Product Name Alternative
OTS-447, OTS 447, FLT3
Field of Research
Cardiovascular Research, Signal Transduction
Purity
97.72% (May vary between batches)
Solubility
DMSO:2.33 mg/mL (5 mM)
Smiles
CCN (CC) C1CCC (CC1) Nc1c (cnc2ccc (cc12) -c1ccc (O) c (Cl) c1) C (C) =O
Molecular Formula
C27H32ClN3O2
Molecular Weight
466.02
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-{6-(3-Chloro-4-hydroxyphenyl)-4-[4-(diethylamino)cyclohexylamino]quinolin-3-yl}ethanone
CAS Number1356943-67-3
PubChem CID66715844
IUPAC Name1-[6-(3-chloro-4-hydroxyphenyl)-4-[[4-(diethylamino)cyclohexyl]amino]quinolin-3-yl]ethanone
Molecular FormulaC27H32ClN3O2
Molecular Weight466.0
XLogP6.4
Topological Polar Surface Area65.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Heavy Atom Count33
Formal Charge0
Complexity637
SMILES
CCN(CC)C1CCC(CC1)NC2=C3C=C(C=CC3=NC=C2C(=O)C)C4=CC(=C(C=C4)O)Cl
InChI
InChI=1S/C27H32ClN3O2/c1-4-31(5-2)21-10-8-20(9-11-21)30-27-22-14-18(19-7-13-26(33)24(28)15-19)6-12-25(22)29-16-23(27)17(3)32/h6-7,12-16,20-21,33H,4-5,8-11H2,1-3H3,(H,29,30)
InChIKey
OSRDFHWWFIEYDB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-{6-(3-Chloro-4-hydroxyphenyl)-4-[4-(diethylamino)cyclohexylamino]quinolin-3-yl}ethanone
CAS: 1356943-67-3
CID: 66715844
Formula: C27H32ClN3O2
MW: 466.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight466.0
XLogP36.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass465.2183050
Monoisotopic Mass465.2183050
Topological Polar Surface Area65.5 Ų
Heavy Atom Count33
Formal Charge0
Complexity637
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA8967-10OTS447

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