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NSC697923

CAT: 0013-GTR19184318-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19184318-02Size:25 mg
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Description
NSC-697923 is a UBE2N (Ubc13) inhibitor that induces neuroblastoma cell death via p53 nuclear import in wild-type cells or JNK-mediated apoptosis in p53-mutant cells. It also suppresses DNA damage and NF-κB signaling, demonstrating antitumor activity in vitro. This compound is a useful research tool for studying ubiquitination, apoptosis pathways, and neuroblastoma models.
CAS Number
343351-67-7
Product Name Alternative
Ubc13, NSC697923, NSC-697923, NSC 697923, 2-[ (4-methylphenyl) sulfonyl]-5-nitrofuran, E3Enzyme, E3 Enzyme, E2Enzyme, E2 Enzyme, E1 Enzyme, E1Enzyme
Field of Research
Cell Biology, Protein Biochemistry
Purity
>98%
Bioactivity
Ubiquitin E2 ligase inhibitor
Form
Powder
Solubility
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 5 mg/ml with warming)
Smiles
Cc1ccc (cc1) S (=O) (=O) c1ccc (o1) [N+] ([O-]) =O
Molecular Formula
C11H9NO5S
Molecular Weight
267.26
Storage Conditions
-20°C
Notes
For research use only.
Other Product Names
2-[ (Methylphenyl) sulfonyl]-5-nitrofuran

Chemical Information

2-((4-Methylphenyl)sulfonyl)-5-nitrofuran

a Ubc13 inhibitor; structure in first source

CAS Number343351-67-7
PubChem CID394449
IUPAC Name2-(4-methylphenyl)sulfonyl-5-nitrofuran
Molecular FormulaC11H9NO5S
Molecular Weight267.26
XLogP2.6
Topological Polar Surface Area101
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Heavy Atom Count18
Formal Charge0
Complexity402
SMILES
CC1=CC=C(C=C1)S(=O)(=O)C2=CC=C(O2)[N+](=O)[O-]
InChI
InChI=1S/C11H9NO5S/c1-8-2-4-9(5-3-8)18(15,16)11-7-6-10(17-11)12(13)14/h2-7H,1H3
InChIKey
GAUHIPWCDXOLCZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-((4-Methylphenyl)sulfonyl)-5-nitrofuran
CAS: 343351-67-7
CID: 394449
Formula: C11H9NO5S
MW: 267.26
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight267.26
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass267.02014356
Monoisotopic Mass267.02014356
Topological Polar Surface Area101 Ų
Heavy Atom Count18
Formal Charge0
Complexity402
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
A8813-10NSC697923

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