NU9056

• Description :

  NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an [1][2] of 2 μM. NU9056 shows >16-fold selectivity for Tip60 over PCAF, p300 and GCN5. NU9056 induces apoptosis of prostate cancer cells[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Histone Acetyltransferase

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Epigenetics

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nu9056.html

• Purity :

  98.81

• Solubility :

  DMSO : 125 mg/mL

• Smiles :

  C1(SSC2=CC=NS2)=CC=NS1

• Molecular Formula :

  C6H4N2S4

• Molecular Weight :

  232.37

• References & Citations :

  [1]Kelly Coffey, et al. Characterisation of a Tip60 specific inhibitor, NU9056, in prostate cancer. PLoS One. 2012;7 (10) :e45539.|[2]Klotilda Narkaj, et al. Blocking H2A.Z Incorporation via Tip60 Inhibition Promotes Systems Consolidation of Fear Memory in Mice. eNeuro. 2018 Nov 8;5 (5) :ENEURO.0378-18.2018.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TIP60

• CAS Number :

  [1450644-28-6]