CK2/ERK8-IN-1

CK2/ERK8-IN-1

• CAS Number: 1085822-09-8
• UNSPSC Description: CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 μM) and ERK8 (MAPK15, ERK7) inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 μM, 15.25 μM, and 11.9 μM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1].
• Target Antigen: Apoptosis; Casein Kinase; DYRK; ERK; Pim
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;JAK/STAT Signaling;MAPK/ERK Pathway;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ck2-erk8-in-1.html
• Smiles: O=C(O)CN1C2=C(Br)C(Br)=C(Br)C(Br)=C2N=C1N(C)C
• Molecular Weight: 534.82
• References & Citations: [1]Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.
• Shipping Conditions: Blue Ice