Anti-Fibrin beta-Chain [8E5]

• NCBI Gene ID:

  2244

• Reactivity:

  Human

• Storage Conditions:

  Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.

• Specificity:

  8E5 binds to the amino-terminal region of the beta-chain of human fibrin at an epitope consiting of GHRPLDKC. Binding is possible in both the monomeric form and the polymeric form of the protein. This peptide sequence is found only in fibrin, and not in its precursor fibrinogen and so there is no cross-reactivity with fibrinogen. Fibrin is a non-globular protein which plays a role in the clotting of blood and circulates as the precursor fibrinogen. Polymerization occurs through the action of the protease thrombin, which results in the active fibrin. Fibrin polymerizes as an insoluble matrix and forms a clot along with platelets over a wound site.

• Other Gene Names:

  [FGB; FGB; HEL-S-78p]

• Short Name:

  [Fibrin beta-Chain]

• Other Product Names:

  [fibrinogen beta chain isoform 2 preproprotein; Fibrinogen beta chain; fibrinogen beta chain; fibrinogen beta chain]

• NCBI GI Number:

  296080754

• NCBI Accession Number:

  NP_001171670.1

• NCBI GB Accession Number:

  NP_001171670.1

• Uniprot Accession Number:

  P02675

• CAS Number:

  9007-83-4