Anti-Lymphotoxin alpha [3F12.2D3]

• Gene Name:

  [LTalpha]

• NCBI Gene ID:

  4049

• Reactivity:

  Human

• Storage Conditions:

  Store at 4 °C for up to 3 months. For longer storage, aliquot and store at -20 °C.

• Specificity:

  3F12 binds to human LTalpha3 and LTalphabeta (with a KD of ~0.3 nM, determined by BIACORE; ~ 37 pM, determined by ELISA) in both its soluble homotrimeric and membrane heterotrimeric forms. LTalpha belongs to the tumor necrosis factor (TNF) superfamily and is secreted as a homo-trimer (LTalpha3), or is expressed on the cell surface in complex with LTbeta. Lymphotoxin is produced by lymphocytes and in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. LTalpha3 signaling induces target cells to upregulate many chemokines and cytokines in an NFkB-dependent manner.

• Other Gene Names:

  [LTA; LTA; LT; TNFB; TNFSF1; TNLG1E; TNFB; TNFSF1; LT-alpha]

• Short Name:

  [Lymphotoxin alpha]

• Other Product Names:

  [lymphotoxin-alpha; Lymphotoxin-alpha; lymphotoxin-alpha; lymphotoxin alpha; TNF-beta; Tumor necrosis factor ligand superfamily member 1]

• NCBI GI Number:

  6806893

• NCBI Accession Number:

  NP_000586.2

• NCBI GB Accession Number:

  NM_000595.3

• Uniprot Accession Number:

  P01374

• CAS Number:

  9007-83-4